2. Gene
  3. NFATC4 - Nfatc4 nuclear factor of activated T-cells 4 Gene

NFATC4 - Nfatc4 nuclear factor of activated T-cells 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as NF-AT3; NF-ATc4

Gene ID: 305897 | Gene type: protein coding

About NFATC4

Summary

Enables DNA-binding transcription factor activity and peroxisome proliferator activated receptor binding activity. Involved in cellular response to ionomycin and regulation of synaptic plasticity. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4). [provided by Alliance of Genome Resources, Apr 2022]

NFATC4 Products(1)

mRNA Protein Name
NM_001107264.1 NP_001100734.1 nuclear factor of activated T-cells, cytoplasmic 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
12954875 RGD
enables peroxisome proliferator activated receptor binding IPI
IPI: Inferred from physical interaction
18600431 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19538478 RGD
involved in regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
12954875 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22343722 RGD
located in nucleus IDA
IDA: Inferred from direct assay
22343722 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear factor of activated T-cells, cytoplasmic 4

T-cell transcription factor NFAT3

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0254 Kisspeptin-10, human 99.86% Unkown
HY-P0254A Kisspeptin-10, human TFA 99.56% Unkown
HY-N1910 4'-O-Methylbavachalcone Inhibitor 99.64% Unkown
HY-RS09242 NFATC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21899 Nfatc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NFATC4 NCBI NCBI:4776