HMGB3 - high mobility group box 3 Gene

Also Known as HMG4; HMG-4; HMG2A; HMG-2a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3149

About HMGB3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:150,980,507-150,990,771 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues, 20 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 24.9), bone marrow (RPKM 7.8) and 21 other tissues.

Summary

This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

HMGB3 Products (4)

mRNA	Protein	Name
NM_001301228.2	NP_001288157.1	high mobility group protein B3 isoform a
NM_001301229.2	NP_001288158.1	high mobility group protein B3 isoform a
NM_001301231.2	NP_001288160.1	high mobility group protein B3 isoform b
NM_005342.4	NP_005333.2	high mobility group protein B3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGB3 Protein Structure

HMG_box_2

HMG_box

0
100
200 a.a.

Protein Preferred Names	Protein Names
high mobility group protein B3	high mobility group protein 2a

HMGB3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HMGB3	O15347	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	HMGB3	O15347	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	HMGB3	O15347	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	HMGB3	O15347	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	HMGB3	O15347	MEOX1	Homo sapiens	P50221	Validated Y2H	32296183
Intra	HMGB3	O15347	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	HMGB3	O15347	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	HMGB3	O15347	PAX5	Homo sapiens	Q02548	Validated Y2H	32296183
Intra	HMGB3	O15347	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	HMGB3	O15347	SDCBP	Homo sapiens	O00560	Y2H Array	31515488
Intra	HMGB3	O15347	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	HMGB3	O15347	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	HMGB3	O15347	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	HMGB3	O15347	PAX6	Homo sapiens	P26367	Validated Y2H	32296183
Intra	HMGB3	O15347	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	HMGB3	O15347	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	HMGB3	O15347	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	HMGB3	O15347	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HMGB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70199	HMGB3/HMG-3 Protein, Human (HEK293, His)	O15347 (M1-E200)	≥ 95%, as determined by reducing SDS-PAGE.

HMGB3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83247	HMG4 Antibody (YA2992)	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
HY-P83247A	HMG4 Antibody (YA2992)(PBS only)	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Microphthalmia, Syndromic 13	X-Linked Colobomatous Microphthalmia-Microcephaly-Intellectual Disability-Short Stature Syndrome MCOPS13 Maine Microphthalmos Colobomatous Microphthalmia With Microcephaly, Short Stature, And Psychomotor Retardation Syndromic Microphthalmia 13 X-Linked Colobomatous Microphthalmia-Microcephaly-Short Stature-Psychomotor Retardation Syndrome Microphthalmia, Syndromic, 13 Microphthalmia, Syndromic, Type 13
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Terminal Osseous Dysplasia	Terminal Osseous Dysplasia And Pigmentary Defects Terminal Osseous Dysplasia-Pigmentary Defects Syndrome Todpd TOD Odpd Odpf Syndrome Osseous Dysplasia, Digital, With Facial Pigmentary Defects And Multiple Frenula Odpf Digital Osseous Dysplasia With Facial Pigmentary Defects And Multiple Frenula Terminal Osseous Dysplasia With Pigmentary Defects Dcd Digitocutaneous Dysplasia Terminal Osseous Dysplasia And Pigmentary Defect Syndrome Osseous Dysplasia And Pigmentary Defects
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06234	HMGB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17980	Hmgb3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24451	Hmgb3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HMGB3	MGD	MGI:1098219
Rattus norvegicus	HMGB3	RGD	RGD:1564407
Canis familiaris	HMGB3	VGNC	VGNC:54164
Others	HMGB3	NCBI