Csk - C-terminal Src kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 315707

Summary

Enables proline-rich region binding activity; protein Phosphatase binding activity; and protein tyrosine kinase activity. Involved in several processes, including central nervous system development; negative regulation of bone resorption; and regulation of MAPK cascade. Located in cytoplasm and membrane raft. Biomarker of hepatocellular carcinoma. Orthologous to human CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Apr 2022]

Csk Products (1)

mRNA Protein Name
NM_001030039.1 NP_001025210.1 tyrosine-protein kinase CSK

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables proline-rich region binding IPI
IPI: Inferred from physical interaction
8890164 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21873224 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
8890164 RGD
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7683130 RGD
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
12700184 RGD
Biological Process GO Annotation Evidence References Source
involved in adherens junction organization IEP
IEP: Inferred from expression pattern
15389520 RGD
involved in cellular response to peptide hormone stimulus IDA
IDA: Inferred from direct assay
17071733 RGD
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
9325302 RGD
involved in negative regulation of bone resorption IDA
IDA: Inferred from direct assay
10411542 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10411542 RGD
involved in negative regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
10411542 RGD
involved in negative regulation of kinase activity IDA
IDA: Inferred from direct assay
10411542 RGD
involved in negative regulation of low-density lipoprotein particle clearance IDA
IDA: Inferred from direct assay
10884975 RGD
involved in negative regulation of phagocytosis IDA
IDA: Inferred from direct assay
10884975 RGD
involved in oligodendrocyte differentiation IEP
IEP: Inferred from expression pattern
15504915 RGD
involved in positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
10884975 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
7683130 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
7683130 RGD
involved in regulation of Fc receptor mediated stimulatory signaling pathway IDA
IDA: Inferred from direct assay
9325302 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21873224 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase CSK

  • C-SRC kinase

  • CSK, non-receptor tyrosine kinase

  • c-src tyrosine kinase

  • protein-tyrosine kinase (CSK)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131669 Dasatinib metabolite M6 Inhibitor 99.39% Unkown
HY-137345 DB-3-291 Degrader 99.08% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csk NCBI NCBI:1445