CSK - C-terminal Src kinase Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1445

About CSK

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,782,080-74,803,197 (from NCBI)

This gene has 14 transcripts (splice variants), 279 orthologues and 32 paralogues. Broad expression in lymph node (RPKM 63.0), spleen (RPKM 47.7) and 24 other tissues.

Summary

The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine Phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the Src proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

CSK Products (13)

mRNA	Protein	Name
NM_001127190.2	NP_001120662.1	tyrosine-protein kinase CSK isoform 1
NM_001354988.2	NP_001341917.1	tyrosine-protein kinase CSK isoform 1
NM_001387089.1	NP_001374018.1	tyrosine-protein kinase CSK isoform 1
NM_001387090.1	NP_001374019.1	tyrosine-protein kinase CSK isoform 1
NM_001387091.1	NP_001374020.1	tyrosine-protein kinase CSK isoform 1
NM_001387092.1	NP_001374021.1	tyrosine-protein kinase CSK isoform 1
NM_001387093.1	NP_001374022.1	tyrosine-protein kinase CSK isoform 1
NM_001387094.1	NP_001374023.1	tyrosine-protein kinase CSK isoform 6
NM_001387095.1	NP_001374024.1	tyrosine-protein kinase CSK isoform 2
NM_001387096.1	NP_001374025.1	tyrosine-protein kinase CSK isoform 3
NM_001387097.1	NP_001374026.1	tyrosine-protein kinase CSK isoform 4
NM_001387098.1	NP_001374027.1	tyrosine-protein kinase CSK isoform 5
NM_004383.3	NP_004374.1	tyrosine-protein kinase CSK isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19888460	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7507203	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	20605918	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IPI IPI: Inferred from physical interaction	10790433	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
450 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase CSK	C-Src kinase

CSK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CSK	P41240	PTPRC	Homo sapiens	P08575	Phosphatase Assay	19167335
Intra	CSK	P41240	FRK	Homo sapiens	P42685	TAP	23455922
Intra	CSK	P41240	FRK	Homo sapiens	P42685	Anti Tag CoIP	28514442
Intra	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Pull Down	10790433
Intra	CSK	P41240	TNS2	Homo sapiens	Q63HR2	TAP	23455922
Intra	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Anti Tag CoIP	33961781
Intra	CSK	P41240	TNS3	Homo sapiens	Q68CZ2	Anti Tag CoIP	31980649
Intra	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Anti Tag CoIP	28514442
Intra	CSK	P41240	TNS2	Homo sapiens	Q63HR2	Pull Down	32707033
Intra	CSK	P41240	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	CSK	P41240	PAG1	Homo sapiens	Q9NWQ8	Pull Down	32707033
Intra	CSK	P41240	FRK	Homo sapiens	P42685	Anti Tag CoIP	33961781
Intra	CSK	P41240	IGF1R	Homo sapiens	P08069	Y2H	10026153
Intra	CSK	P41240	IGF1R	Homo sapiens	P08069	CoIP	10026153
Intra	CSK	P41240	PXN	Homo sapiens	P49023	Anti Bait CoIP	14665621
Intra	CSK	P41240	PXN	Homo sapiens	P49023	Anti Tag CoIP	31980649
Intra	CSK	P41240	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CSK	P41240	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CSK	P41240	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	CSK	P41240	KANK4	Homo sapiens	Q5T7N3	Y2H Array	32296183
Intra	CSK	P41240	KANK4	Homo sapiens	Q5T7N3	Y2H Prey Pooling	32296183
Intra	CSK	P41240	KANK4	Homo sapiens	Q5T7N3	Validated Y2H	32296183
Cross	CSK	P41240	SRC	Gallus gallus	P00523	X-Ray Diffraction	18614016
Cross	CSK	P41240	SRC	Gallus gallus	P00523	Protein Kinase Assay	15683240
Cross	CSK	P41240	SRC	Gallus gallus	P00523	SPR	18614016
Cross	CSK	P41240	lspA1	Haemophilus ducreyi	Q7VLE8	Protein Kinase Assay	24902122
Cross	CSK	P41240	lspA1	Haemophilus ducreyi	Q7VLE8	Pull Down	24902122

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72956	CSK Protein, Human (Active, sf9, GST)	P41240 (M1-L450)	≥ 90%, as determined by reducing SDS-PAGE.

CSK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82997	CSK Antibody (YA2742)	WB, IHC-P	Human, Mouse, Rat
HY-P84308	CSK Antibody (YA4005)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey, Rat
HY-P84308A	CSK Antibody (YA4005)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey, Rat
HY-P85111	CSK Antibody (YA4803)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P85546	CSK Antibody (YA5238)	WB, ICC/IF	Human, Rat

Related Diseases

Diseases	Alias
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Cd45 Deficiency
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131669	Dasatinib metabolite M6	Inhibitor	99.39%	Unkown
HY-137345	DB-3-291	Degrader	99.08%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CSK	RGD	RGD:1308800
Mus musculus	CSK	MGD	MGI:88537
Macaca mulatta	CSK	VGNC	VGNC:81380
Canis familiaris	CSK	VGNC	VGNC:39661
Felis catus	CSK	VGNC	VGNC:61220
Bos taurus	CSK	VGNC	VGNC:27761
Others	CSK	NCBI