1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. DB-3-291

DB-3-291 

Cat. No.: HY-137345
Handling Instructions

DB-3-291 is potent and selective CSK degrader, with a Kd of 1 nM.

For research use only. We do not sell to patients.

DB-3-291 Chemical Structure

DB-3-291 Chemical Structure

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Description

DB-3-291 is potent and selective CSK degrader, with a Kd of 1 nM[1].

IC50 & Target

CSK[1]

Molecular Weight

886.37

Formula

C41H44ClN11O8S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (56.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1282 mL 5.6410 mL 11.2820 mL
5 mM 0.2256 mL 1.1282 mL 2.2564 mL
10 mM 0.1128 mL 0.5641 mL 1.1282 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (5.64 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References
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  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
DB-3-291
Cat. No.:
HY-137345
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