2769753-64-0
Chemical Structure
DB-3-291
- CAS No.: 2769753-64-0
- Formula:C41H44ClN11O8S
- Molecular Weight:886.37
IUPAC Name: N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-((4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)amino)-2-oxoethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
InChIKey: NYBFKYHLTFWMOL-UHFFFAOYSA-N
SMILES: O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3OCC(NCCCCNC(CN4CCN(C5=CC(NC6=NC=C(C(NC7=C(Cl)C=CC=C7C)=O)S6)=NC(C)=N5)CC4)=O)=O)=O
Biological Activity: DB-3-291 is a CSK-targeting agent with a human CSK Kd of 1 nM and high selectivity for CSK over other kinases bound by dasatinib. DB-3-291 induces targeted degradation of CSK via a ubiquitin-dependent pathway and incorporates dasatinib as the kinase binding ligand. DB-3-291 can be used for the research of innate immune responses to viral DNA[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DB-3-291 | 99.08% | DB-3-291 is a CSK-targeting agent with a human CSK Kd of 1 nM and high selectivity for CSK over other kinases bound by dasatinib. DB-3-291 induces targeted degradation of CSK via a ubiquitin-dependent pathway and incorporates dasatinib as the kinase binding ligand. DB-3-291 can be used for the research of innate immune responses to viral DNA. | ||||||||||||||||||||
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