2. Gene
  3. Nck2 - NCK adaptor protein 2 Gene

Nck2 - NCK adaptor protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 316369 | Gene type: protein coding

About Nck2

Summary

Predicted to enable several functions, including phosphotyrosine residue binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in postsynaptic density. Orthologous to human NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Nck2 Products(1)

mRNA Protein Name
NM_001108216.1 NP_001101686.1 cytoplasmic protein NCK2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within dendritic spine development IGI
IGI: Inferred from genetic interaction
17310244 RGD
acts upstream of or within immunological synapse formation IGI
IGI: Inferred from genetic interaction
17310244 RGD
Cellular Component GO Annotation Evidence Reference Source
located in postsynaptic density IDA
IDA: Inferred from direct assay
17310244 RGD
located in synapse IDA
IDA: Inferred from direct assay
17310244 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic protein NCK2

non-catalytic region of tyrosine kinase adaptor protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0710 alpha-Cyperone 99.68% Unkown
HY-173156 UNC10013 Modulator 99.90% Unkown
HY-171744 CX-5279 Inhibitor / Unkown
HY-RS09081 NCK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nck2 NCBI NCBI:8440