INPP5A - inositol polyphosphate-5-phosphatase A Gene

Homo sapiens

Also known as 5PTASE

Gene ID: 3632 | Gene type: protein coding

About INPP5A

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:132,537,787-132,783,480 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in heart (RPKM 7.6), testis (RPKM 4.7) and 25 other tissues.

Summary

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

INPP5A Products(2)

mRNA	Protein	Name
NM_001321042.2	NP_001307971.1	inositol polyphosphate-5-phosphatase A isoform b
NM_005539.5	NP_005530.3	inositol polyphosphate-5-phosphatase A isoform a

INPP5A Protein Structure

Exo_endo_phos

0
100
200
300
412 a.a.

Protein Preferred Names

Protein Names

inositol polyphosphate-5-phosphatase A

43 kDa inositol polyphosphate 5-phophatase

Recombinant INPP5A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70834	INPP5A Protein, Human (HEK293, His)	Q14642 (M1-V410)	≥95%

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 17

Spinocerebellar Ataxia Type 17	SCA17
Huntington Disease-Like 4	Hdl4
Olivopontocerebellar Atrophy V	Cerebelloparenchymal Disorder Ii
Opca5	Cpd2
Sca 17	Ataxia, Spinocerebellar, Type 17

Lowe Oculocerebrorenal Syndrome

Lowe Syndrome	Oculocerebrorenal Syndrome
OCRL	Oculocerebrorenal Syndrome Of Lowe
Ocrl1	Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency
Lowe Disease	Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency
Cerebrooculorenal Syndrome	Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency
Lowe Oculo-Cerebro-Renal Dystrophy	Lowe Oculo-Cerebro-Renal Syndrome
Lowe Oculocerebrorenal Dystrophy	Low
Chromosome 11p Deletion Syndrome	Oculocerebrorenal Dystrophy
Cerebro-Oculorenal Dystrophy	Ocrl1 - [Oculocerebrorenal Syndrome]
Lowe-Terrey-Maclachlan Syndrome	Renal-Oculocerebrodystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06827	INPP5A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	INPP5A	RGD	RGD:1306168
Bos taurus	INPP5A	VGNC	VGNC:30210
Mus musculus	INPP5A	MGD	MGI:2686961
Macaca mulatta	INPP5A	VGNC	VGNC:73749
Canis familiaris	INPP5A	VGNC	VGNC:42030
Felis catus	INPP5A	VGNC	VGNC:67807
Others	INPP5A	NCBI

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