INPP5A - inositol polyphosphate-5-phosphatase A Gene

Also Known as 5PTASE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3632

About INPP5A

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:132,537,787-132,783,480 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in heart (RPKM 7.6), testis (RPKM 4.7) and 25 other tissues.

Summary

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

INPP5A Products (2)

mRNA Protein Name
NM_001321042.2 NP_001307971.1 inositol polyphosphate-5-phosphatase A isoform b
NM_005539.5 NP_005530.3 inositol polyphosphate-5-phosphatase A isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PH domain binding IPI
IPI: Inferred from physical interaction
8999861 GOA
enables inositol-polyphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
8006039 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8999861 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
8006039 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
8626616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INPP5A Protein Structure

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (15 - 373)

  • 0
  • 100
  • 200
  • 300
  • 412 a.a.
Protein Preferred Names Protein Names

inositol polyphosphate-5-phosphatase A

  • 43 kDa inositol polyphosphate 5-phophatase

INPP5A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INPP5A Q14642 PLEK Homo sapiens P08567
Enzymatic Study
8999861
Intra
INPP5A Q14642 TEAD2 Homo sapiens Q15562-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant INPP5A Proteins

Cat. No. Product Name Accession Purity
HY-P70834 INPP5A Protein, Human (HEK293, His) Q14642 (M1-V410) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 17

  • Spinocerebellar Ataxia Type 17

  • SCA17

  • Huntington Disease-Like 4

  • Hdl4

  • Olivopontocerebellar Atrophy V

  • Cerebelloparenchymal Disorder Ii

  • Opca5

  • Cpd2

  • Sca 17

  • Ataxia, Spinocerebellar, Type 17
Lowe Oculocerebrorenal Syndrome

  • Lowe Syndrome

  • Oculocerebrorenal Syndrome

  • OCRL

  • Oculocerebrorenal Syndrome Of Lowe

  • Ocrl1

  • Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency

  • Lowe Disease

  • Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency

  • Cerebrooculorenal Syndrome

  • Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency

  • Lowe Oculo-Cerebro-Renal Dystrophy

  • Lowe Oculo-Cerebro-Renal Syndrome

  • Lowe Oculocerebrorenal Dystrophy

  • Low

  • Chromosome 11p Deletion Syndrome

  • Oculocerebrorenal Dystrophy

  • Cerebro-Oculorenal Dystrophy

  • Ocrl1 - [Oculocerebrorenal Syndrome]

  • Lowe-Terrey-Maclachlan Syndrome

  • Renal-Oculocerebrodystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06827 INPP5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21876 Inpp5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28393 Inpp5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus INPP5A RGD RGD:1306168
Bos taurus INPP5A VGNC VGNC:30210
Mus musculus INPP5A MGD MGI:2686961
Macaca mulatta INPP5A VGNC VGNC:73749
Canis familiaris INPP5A VGNC VGNC:42030
Felis catus INPP5A VGNC VGNC:67807
Others INPP5A NCBI