KTN1 - kinectin 1 Gene

Also Known as CG1; KNT; MU-RMS-40.19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3895

About KTN1

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,580,207-55,684,584 (from NCBI)

This gene has 25 transcripts (splice variants), 206 orthologues and is associated with 76 phenotypes. Ubiquitous expression in testis (RPKM 35.7), thyroid (RPKM 26.9) and 25 other tissues.

Summary

This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds Kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]

KTN1 Products (32)

mRNA	Protein	Name
NM_001079521.2	NP_001072989.1	kinectin isoform a
NM_001079522.2	NP_001072990.1	kinectin isoform b
NM_001271014.2	NP_001257943.1	kinectin isoform d
NM_001402682.1	NP_001389611.1	kinectin isoform a
NM_001402683.1	NP_001389612.1	kinectin isoform 5
NM_001402684.1	NP_001389613.1	kinectin isoform 6
NM_001402685.1	NP_001389614.1	kinectin isoform d
NM_001402686.1	NP_001389615.1	kinectin isoform d
NM_001402687.1	NP_001389616.1	kinectin isoform 7
NM_001402688.1	NP_001389617.1	kinectin isoform 7
NM_001402689.1	NP_001389618.1	kinectin isoform 7
NM_001402690.1	NP_001389619.1	kinectin isoform b
NM_001402691.1	NP_001389620.1	kinectin isoform b
NM_001402692.1	NP_001389621.1	kinectin isoform 8
NM_001402693.1	NP_001389622.1	kinectin isoform c
NM_001402694.1	NP_001389623.1	kinectin isoform c
NM_001402696.1	NP_001389625.1	kinectin isoform 9
NM_001402698.1	NP_001389627.1	kinectin isoform 10
NM_001402699.1	NP_001389628.1	kinectin isoform 11
NM_001402700.1	NP_001389629.1	kinectin isoform 11
NM_001402701.1	NP_001389630.1	kinectin isoform 12
NM_001402702.1	NP_001389631.1	kinectin isoform 12
NM_001402703.1	NP_001389632.1	kinectin isoform 13
NM_001402704.1	NP_001389633.1	kinectin isoform 14
NM_001402705.1	NP_001389634.1	kinectin isoform 14
NM_001402706.1	NP_001389635.1	kinectin isoform 15
NM_001402707.1	NP_001389636.1	kinectin isoform 16
NM_001402708.1	NP_001389637.1	kinectin isoform 17
NM_001402709.1	NP_001389638.1	kinectin isoform 18
NM_001402710.1	NP_001389639.1	kinectin isoform 19
NM_001402711.1	NP_001389640.1	kinectin isoform 20
NM_004986.4	NP_004977.2	kinectin isoform c

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
kinectin	CG-1 antigen

KTN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KTN1	Q86UP2	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	KTN1	Q86UP2	CLEC7A	Homo sapiens	Q9BXN2	Y2H Prey Pooling	25416956
Intra	KTN1	Q86UP2	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	KTN1	Q86UP2	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

KTN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811272	Kinectin 1 Antibody	WB, ICC/IF	Human, Mouse
HY-P89575	Kinectin 1 Antibody (YA8919)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Gliofibroma
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07477	KTN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KTN1	RGD	RGD:1308719
Bos taurus	KTN1	VGNC	VGNC:30756
Felis catus	KTN1	VGNC	VGNC:67997
Macaca mulatta	KTN1	VGNC	VGNC:74222
Canis familiaris	KTN1	VGNC	VGNC:42550
Mus musculus	KTN1	MGD	MGI:109153
Others	KTN1	NCBI