LGALS2 - galectin 2 Gene

Also Known as HL14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3957

About LGALS2

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,570,248-37,580,087 (from NCBI)

This gene has 2 transcripts (splice variants), 325 orthologues, 16 paralogues and is associated with 1 phenotype. Biased expression in gall bladder (RPKM 133.8), small intestine (RPKM 81.3) and 7 other tissues.

Summary

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]

LGALS2 Products (1)

mRNA Protein Name
NM_006498.3 NP_006489.1 galectin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell homeostasis IDA
IDA: Inferred from direct assay
15356130 GOA
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
15356130 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
15356130 GOA
Cellular Component GO Annotation Evidence References Source
part of galectin complex IPI
IPI: Inferred from physical interaction
8262940 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGALS2 Protein Structure

Gal-bind_lectin

Gal-bind_lectin: Galactoside-binding lectin (7 - 128)

  • 0
  • 100
  • 132 a.a.
Protein Preferred Names Protein Names

galectin-2

  • S-Lac lectin 2

LGALS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LGALS2 P05162 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
LGALS2 P05162 SDCBP Homo sapiens O00560
Y2H Array
25416956
Intra
LGALS2 P05162 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
LGALS2 P05162 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Array
31515488
Intra
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
Intra
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Validated Y2H
32296183
Intra
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
32296183
Intra
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Array
32296183
Intra
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LGALS2 Proteins

Cat. No. Product Name Accession Purity
HY-P700078AF Animal-Free Galectin-2/LGALS2 Protein, Human (His) P05162 (T2-E132) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700301 Galectin-2/LGALS2 Protein, Human (GST) P05162 (M1-E132) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Blackwater Fever

  • Black Water Fever

  • Hemoglobinuric, Malaria

  • Malarial Hemoglobinuria
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07604 LGALS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07603 LGALS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20173 Lgals2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26677 Lgals2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LGALS2 VGNC VGNC:74254
Mus musculus LGALS2 MGD MGI:895068
Felis catus LGALS2 VGNC VGNC:68039
Canis familiaris LGALS2 VGNC VGNC:42647
Rattus norvegicus LGALS2 RGD RGD:621269
Bos taurus LGALS2 VGNC VGNC:50210
Others LGALS2 NCBI