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LRPAP1 - LDL receptor related protein associated protein 1 Gene

Also Known as RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4043

About LRPAP1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,503,612-3,532,422 (from NCBI)

This gene has 6 transcripts (splice variants), 192 orthologues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 14.2), placenta (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

LRPAP1 Products (1)

mRNA	Protein	Name
NM_002337.4	NP_002328.1	alpha-2-macroglobulin receptor-associated protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables low-density lipoprotein particle receptor binding	IDA IDA: Inferred from direct assay	7774585	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8083232	GOA
enables receptor antagonist activity	IDA IDA: Inferred from direct assay	8083232	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	11294867	GOA
enables very-low-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	8083232	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance by transcytosis	IMP IMP: Inferred from mutant phenotype	26005850	GOA
involved in negative regulation of amyloid-beta clearance	IGI IGI: Inferred from genetic interaction	19098903	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	8083232	GOA
involved in negative regulation of receptor internalization	IGI IGI: Inferred from genetic interaction	23386614	GOA
involved in negative regulation of very-low-density lipoprotein particle clearance	IDA IDA: Inferred from direct assay	8083232	GOA
involved in regulation of receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	7774585	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	11294867	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	7774585	GOA
located in cis-Golgi network	IDA IDA: Inferred from direct assay	7774585	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	7774585	GOA
located in endosome	IDA IDA: Inferred from direct assay	7774585	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16263759	GOA
located in rough endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	7774585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRPAP1 Protein Structure

Alpha-2-MRAP_N

Alpha-2-MRAP_C

0
100
200
300
357 a.a.

Protein Preferred Names	Protein Names
alpha-2-macroglobulin receptor-associated protein	39 kDa receptor-associated protein

LRPAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRPAP1	P30533	LRP1	Homo sapiens	Q07954	Anti Tag CoIP	33961781
Intra	LRPAP1	P30533	LRP1	Homo sapiens	Q07954	NMR	20030366
Intra	LRPAP1	P30533	LRP1	Homo sapiens	Q07954	Anti Tag CoIP	28514442
Intra	LRPAP1	P30533	SORT1	Homo sapiens	Q99523	Photoaffinity Labelling	10085125
Intra	LRPAP1	P30533	SORL1	Homo sapiens	Q92673	Anti Tag CoIP	33961781
Intra	LRPAP1	P30533	SORL1	Homo sapiens	Q92673	Anti Tag CoIP	28514442
Intra	LRPAP1	P30533	SORL1	Homo sapiens	Q92673	SPR	26858303
Intra	LRPAP1	P30533	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183
Intra	LRPAP1	P30533	LRP8	Homo sapiens	Q14114	Anti Tag CoIP	33961781
Intra	LRPAP1	P30533	LRP8	Homo sapiens	Q14114	Anti Tag CoIP	20223215
Intra	LRPAP1	P30533	VLDLR	Homo sapiens	P98155	Anti Tag CoIP	33961781
Intra	LRPAP1	P30533	VLDLR	Homo sapiens	P98155	Far-WB	8083232
Intra	LRPAP1	P30533	VLDLR	Homo sapiens	P98155	ELISA	8083232
Intra	LRPAP1	P30533	LDLR	Homo sapiens	P01130	Anti Tag CoIP	33961781
Intra	LRPAP1	P30533	LDLR	Homo sapiens	P01130	Pull Down	20030366
Intra	LRPAP1	P30533	LDLR	Homo sapiens	P01130	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRPAP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76478	LRPAP1 Protein, Human (HEK293, His, solution)	P30533 (Y35-L357)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Myopia 23, Autosomal Recessive	MYP23 Myopia, Type 23, Autosomal Recessive
Rare Isolated Myopia
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Refractive Error	Refractive Errors
Axenfeld-Rieger Syndrome, Type 2	Axenfeld-Rieger Syndrome Type 2 RIEG2 Rieger Syndrome, Type 2 Rieger Syndrome Type 2 Rieger Syndrome 2
Glomerulonephritis	Bright'S Disease
Membranous Nephropathy	Membranous Glomerulonephritis Glomerulonephritis, Membranous Idiopathic Membranous Nephropathy Idiopathic Membranous Glomerulonephritis MBNP Membranous Nephropathy, Susceptibility To Extramembranous Glomerulonephritis Mgn Membranous Gn Primary Membranous Glomerulonephritis Primary Membranous Nephropathy Nephropathy Membranous
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0009A	Cetrorelix Acetate	Antagonist	99.98%	Unkown
HY-P0009B	Cetrorelix diacetate	Antagonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07803	LRPAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18095	Lrpap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24570	Lrpap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRPAP1	RGD	RGD:620700
Canis familiaris	LRPAP1	VGNC	VGNC:42780
Felis catus	LRPAP1	VGNC	VGNC:68093
Mus musculus	LRPAP1	MGD	MGI:96829
Bos taurus	LRPAP1	VGNC	VGNC:30995
Macaca mulatta	LRPAP1	VGNC	VGNC:74448
Others	LRPAP1	NCBI