LRPAP1 - LDL receptor related protein associated protein 1 Gene

Homo sapiens

Also known as RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP

Gene ID: 4043 | Gene type: protein coding

About LRPAP1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,503,612-3,532,422 (from NCBI)

This gene has 6 transcripts (splice variants), 192 orthologues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 14.2), placenta (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

LRPAP1 Products(1)

mRNA	Protein	Name
NM_002337.4	NP_002328.1	alpha-2-macroglobulin receptor-associated protein precursor

LRPAP1 Protein Structure

Alpha-2-MRAP_N

Alpha-2-MRAP_C

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

alpha-2-macroglobulin receptor-associated protein

39 kDa receptor-associated protein

Recombinant LRPAP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76478	LRPAP1 Protein, Human (HEK293, His)	P30533 (Y35-L357)	≥95%

Related Diseases

Diseases

Alias

Myopia 23, Autosomal Recessive

MYP23

Myopia, Type 23, Autosomal Recessive

Rare Isolated Myopia

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Refractive Error

Refractive Errors

Axenfeld-Rieger Syndrome, Type 2

Axenfeld-Rieger Syndrome Type 2	RIEG2
Rieger Syndrome, Type 2	Rieger Syndrome Type 2
Rieger Syndrome 2

Glomerulonephritis

Bright'S Disease

Membranous Nephropathy

Membranous Glomerulonephritis	Glomerulonephritis, Membranous
Idiopathic Membranous Nephropathy	Idiopathic Membranous Glomerulonephritis
MBNP	Membranous Nephropathy, Susceptibility To
Extramembranous Glomerulonephritis	Mgn
Membranous Gn	Primary Membranous Glomerulonephritis
Primary Membranous Nephropathy	Nephropathy Membranous

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0009A	Cetrorelix Acetate	Antagonist	99.87%	Unkown
HY-P0009B	Cetrorelix diacetate	Antagonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07803	LRPAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRPAP1	RGD	RGD:620700
Canis familiaris	LRPAP1	VGNC	VGNC:42780
Felis catus	LRPAP1	VGNC	VGNC:68093
Mus musculus	LRPAP1	MGD	MGI:96829
Bos taurus	LRPAP1	VGNC	VGNC:30995
Macaca mulatta	LRPAP1	VGNC	VGNC:74448
Others	LRPAP1	NCBI

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