ARR3 - arrestin 3 Gene

Also Known as ARRX; cArr; MYP26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 407

About ARR3

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,268,334-70,281,883 (from NCBI)

This gene has 4 transcripts (splice variants), 262 orthologues, 3 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a non-visual Arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]

ARR3 Products (1)

mRNA	Protein	Name
NM_004312.3	NP_004303.2	arrestin-C

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	23704327	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARR3 Protein Structure

Arrestin_N

Arrestin_C

0
100
200
300
388 a.a.

Protein Preferred Names	Protein Names
arrestin-C	C-arrestin

ARR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARR3	P36575	ZBTB43	Homo sapiens	O43298	Y2H Array	25416956
Intra	ARR3	P36575	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	25416956
Intra	ARR3	P36575	ZNF496	Homo sapiens	Q96IT1	Y2H Pooling	16189514
Intra	ARR3	P36575	ZNF496	Homo sapiens	Q96IT1	Pull Down	16189514
Intra	ARR3	P36575	ZNF496	Homo sapiens	Q96IT1	Lumier	32814053
Intra	ARR3	P36575	PLK4	Homo sapiens	O00444	Y2H Array	25416956
Intra	ARR3	P36575	PLK4	Homo sapiens	O00444	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Myopia 26, X-Linked, Female-Limited	MYP26 Myopia, Type 26, X-Linked, Female-Limited
Refractive Error	Refractive Errors
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Oguchi Disease 1	Oguchi Disease-1 CSNBO1 Night Blindness, Congenital Stationary, Oguchi Type 1 Congenital Stationary Night Blindness Oguchi Type 1 Oguchi Disease
Oguchi Disease 2	Oguchi Disease-2 CSNBO2 Night Blindness, Congenital Stationary, Oguchi Type 2 Congenital Stationary Night Blindness Oguchi Type 2
Retinal Vasculitis
Night Blindness, Congenital Stationary, Type 2a	Congenital Stationary Night Blindness 2a CSNB2A Csnb2 Csnb, Incomplete, X-Linked Night Blindness, Congenital Stationary, Type 2 Night Blindness, Congenital Stationary , 2a, X-Linked Congenital Stationary Night Blindness 2a X-Linked Night Blindness, Congenital Stationary, 2a Congenital Stationary Night Blindness Type 2 Incomplete X-Linked Csnb Night Blindness, Congenital Stationary, X-Linked, Type 2a Blindness, Night, Stationary, Congenital, Type 2a
Myasthenic Syndrome, Congenital, 3a, Slow-Channel	Congenital Myasthenic Syndrome 3a CMS3A Congenital Myasthenic Syndrome 3a, Slow-Channel Myasthenic Syndrome, Congenital, Type 3a, Slow-Channel
Retinal Degeneration	Degeneration Of Retina
Cone-Rod Dystrophy 6	CORD6 Retinal Cone Dystrophy 2 Rcd2 Dystrophy, Cone-Rod, Type 6 Retinitis Pigmentosa 6 Progressive Cone Degeneration Cone Dystrophy
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Leber Congenital Amaurosis 1	LCA1 Amaurosis Congenita Of Leber I Lca Retinal Blindness, Congenital Crb Leber Congenital Amaurosis Type I Leber Congenital Amaurosis, Type 1 Amaurosis Congenita Of Leber, Type 1
Achromatopsia	Achm Rod Monochromatism Total Color Blindness Rod Monochromacy Monochromatism Achromatism Complete Or Incomplete Color Blindness Pingelapese Blindness Achromatopsia 1 Achromatopsia 2 Achromatopsia 3
Color Blindness	Color Vision Defect Blindness Color Colour Blindness Colour Vision Deficiency Color Vision Deficiency Color Vision Defects Defective Color Vision Vision Defect, Color Color-Vision Disease Dyschromatopsia
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Eye Degenerative Disease
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary Congenital Essential Nyctalopia Oguchi Disease Blindness, Night, Stationary, Congenital
Cone Dystrophy	Retinal Cone Dystrophy Dystrophy, Cone Cone Dystrophy 3
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01027	ARR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20857	Arrb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARR3	VGNC	VGNC:38135
Felis catus	ARR3	VGNC	VGNC:68258
Mus musculus	ARR3	MGD	MGI:2159617
Rattus norvegicus	ARR3	RGD	RGD:621385
Bos taurus	ARR3	VGNC	VGNC:26168
Macaca mulatta	ARR3	VGNC	VGNC:70020
Others	ARR3	NCBI