SNU13 - small nuclear ribonucleoprotein 13 Gene

Also Known as FA1; FA-1; NHPX; 15.5K; OTK27; SSFA1; NHP2L1; SPAG12; SNRNP15-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4809

About SNU13

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,673,933-41,690,480 (from NCBI)

This gene has 12 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in brain (RPKM 32.6), adrenal (RPKM 31.2) and 25 other tissues.

Summary

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SNU13 Products (2)

mRNA Protein Name
NM_001003796.2 NP_001003796.1 NHP2-like protein 1
NM_005008.4 NP_004999.1 NHP2-like protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
17636026 GOA
enables U3 snoRNA binding IDA
IDA: Inferred from direct assay
11081632 GOA
enables U4 snRNA binding IDA
IDA: Inferred from direct assay
11081632 GOA
enables U4atac snRNA binding IDA
IDA: Inferred from direct assay
16857676 GOA
enables box C/D sno(s)RNA binding IDA
IDA: Inferred from direct assay
11081632 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10593953 GOA
contributes to snoRNA binding IDA
IDA: Inferred from direct assay
17636026 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: Inferred from direct assay
26912367 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: Inferred from physical interaction
30975767 GOA
part of U4atac snRNP IDA
IDA: Inferred from direct assay
21784869 GOA
part of box C/D methylation guide snoRNP complex IDA
IDA: Inferred from direct assay
11081632 GOA
located in dense fibrillar component IDA
IDA: Inferred from direct assay
10593953 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
10593953 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28781166 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
17636026 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNU13 Protein Structure

Ribosomal_L7Ae

Ribosomal_L7Ae: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (21 - 111)

  • 0
  • 100
  • 128 a.a.
Protein Preferred Names Protein Names

NHP2-like protein 1

  • NHP2 non-histone chromosome protein 2-like 1

SNU13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SNU13 P55769 NUFIP1 Homo sapiens Q9UHK0
Pull Down
17636026
Intra
SNU13 P55769 SMN1 Homo sapiens Q16637
Y2H Prey Pooling
32296183
Intra
SNU13 P55769 SMN1 Homo sapiens Q16637
Validated Y2H
32296183
Intra
SNU13 P55769 SMN1 Homo sapiens Q16637
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SNU13 Proteins

Cat. No. Product Name Accession Purity
HY-P71161 NHP2L1 Protein, Human (His) P55769 (M1-V128) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Microcephalic Osteodysplastic Primordial Dwarfism, Type I

  • Taybi-Linder Syndrome

  • Brachymelic Primordial Dwarfism

  • Cephaloskeletal Dysplasia

  • Low-Birth-Weight Dwarfism With Skeletal Dysplasia

  • Microcephalic Osteodysplastic Primordial Dwarfism Type I

  • Osteodysplastic Primordial Dwarfism Type I

  • Primordial Microcephalic Dwarfism, Crachami Type

  • Osteodysplastic Primordial Dwarfism, Type 1

  • MOPD1

  • Mopd I

  • Mopd

  • Osteodysplastic Primordial Dwarfism, Type I

  • Tals

  • Microcephalic Osteodysplastic Primordial Dwarfism Type 1

  • Mopd 1

  • Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3

  • Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii

  • Mopd Types I And Iii

  • Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type

  • Primordial Microcephalic Dwarfism Crachami Type

  • Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Dyskeratosis Congenita

  • Dyskeratosis Congenita Autosomal Dominant

  • Dc

  • Dkc

  • Zinsser-Engman-Cole Syndrome

  • Dyskeratosis Congenita, Autosomal Dominant

  • Autosomal Dominant Dyskeratosis Congenita

  • Dkca

  • Dyskeratosis Congenita Scoggins Type

  • Zinsser-Cole-Engman Syndrome

  • X-Linked Dyskeratosis Congenita

  • Hoyeraal-Hreidarsson Syndrome
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179117 RNA splicing modulator 5 Inhibitor / Unkown
HY-RS13518 SNU13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21048 Snu13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27566 Snu13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SNU13 VGNC VGNC:98450
Mus musculus SNU13 MGD MGI:893586
Rattus norvegicus SNU13 RGD RGD:1303103
Bos taurus SNU13 VGNC VGNC:35087
Others SNU13 NCBI