country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

CHST15 - carbohydrate sulfotransferase 15 Gene

Also Known as BRAG; GALNAC4S-6ST

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51363

About CHST15

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:124,007,668-124,093,598 (from NCBI)

This gene has 5 transcripts (splice variants) and 266 orthologues. Ubiquitous expression in ovary (RPKM 9.9), spleen (RPKM 9.5) and 25 other tissues.

Summary

Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II Transmembrane Glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

CHST15 Products (4)

mRNA	Protein	Name
NM_001270764.2	NP_001257693.1	carbohydrate sulfotransferase 15 isoform 1
NM_001270765.2	NP_001257694.1	carbohydrate sulfotransferase 15 isoform 2
NM_014863.4	NP_055678.2	carbohydrate sulfotransferase 15 isoform 2
NM_015892.5	NP_056976.2	carbohydrate sulfotransferase 15 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 3'-phosphoadenosine 5'-phosphosulfate binding	IDA IDA: Inferred from direct assay	11572857	GOA
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity	IDA IDA: Inferred from direct assay	11572857	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26496610	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hexose biosynthetic process	IDA IDA: Inferred from direct assay	11572857	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHST15 Protein Structure

Sulfotransfer_1

0
100
200
300
400
500
561 a.a.

Protein Preferred Names	Protein Names
carbohydrate sulfotransferase 15	B cell RAG associated protein (GALNAC4S-6ST)

CHST15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHST15	Q7LFX5	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CHST15	Q7LFX5	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CHST15	Q7LFX5	CANX	Homo sapiens	P27824	Anti Tag CoIP	26496610
Intra	CHST15	Q7LFX5	CANX	Homo sapiens	P27824	Anti Tag CoIP	28514442
Intra	CHST15	Q7LFX5	CANX	Homo sapiens	P27824	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CHST15 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76258	CHST15 Protein, Human (HEK293, His)	Q7LFX5-1 (S99-T561)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Spondyloepiphyseal Dysplasia With Congenital Joint Dislocations	Spondyloepiphyseal Dysplasia Chst3-Related Skeletal Dysplasia Humerospinal Dysostosis Spondyloepiphyseal Dysplasia, Omani Type Chondrodysplasia With Multiple Dislocations SEDCJD Hsd Cdmd Humero-Spinal Dysostosis Kozlowski Celermajer Tink Syndrome Chondrodysplasia With Congenital Joint Dislocations, Chst3 Type Larsen Syndrome, Recessive Type Humero-Spinal Dysostosis With Congenital Heart Disease Omani Type Sed Chst3 Deficiency Chst3-Related Dysplasia Recessive Larsen Syndrome Autosomal Recessive Larsen Syndrome Sed With Luxations, Chst3 Type Sed, Omani Type Sdcd, Chst3 Type Spondyloepiphyseal Dysplasia With Congenital Joint Dyslocations, Chst3 Type Sed Omani Type Spondyloepiphyseal Dysplasia Omani Type Larsen Syndrome, Autosomal Recessive Mucopolysaccharidosis Iv Spondyloepiphyseal Dysplasia, Congenita
Larsen Syndrome	LRS Larsen Syndrome, Dominant Type Dominant Larsen Syndrome Autosomal Dominant Larsen Syndrome Larsens Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124704	Chst15-IN-1	Inhibitor	98.01%	Unkown
HY-RS02687	CHST15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19769	Chst15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26266	Chst15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHST15	MGD	MGI:1924840
Rattus norvegicus	CHST15	RGD	RGD:628881
Bos taurus	CHST15	VGNC	VGNC:27343
Macaca mulatta	CHST15	VGNC	VGNC:70999
Felis catus	CHST15	VGNC	VGNC:60889
Canis familiaris	CHST15	VGNC	VGNC:39253
Others	CHST15	NCBI