Chst15-IN-1
Based on 1 publication(s) in Google Scholar
Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair.
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- 純度 : 98.01%
- CAS 番号: 2158198-77-5
- 分子式: C17H11BrCl2N2O3
- 分子量:442.09
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Chst15-IN-1
More
生物活性
製品説明
IC50 & Target
Chst15[1]
体外実験
Chst15-IN-1 (25 μM; 24 hours; Neu7 astrocytes) is selective for sulfotransferases over the myriad of reactive cysteine-containing proteins. Chst15-IN-1 (10 and 25 μM; Neu7 astrocytes) shows a significant dose dependent decrease in cell-surface CS-E expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats
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Dosage:3.0 mg/kg (Pharmacokinetic Analysis)
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Administration:I.v.
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Result:Had a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 h.
化学情報
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CAS 番号 2158198-77-5
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性状 Solid
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分子量 442.09
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分子式 C17H11BrCl2N2O3
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Color Light yellow to yellow
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SMILES
O=C(NC1=CC=C(Cl)C=C1Cl)/C(C#N)=C/C2=CC(OC)=C(O)C(Br)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (113.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2620 mL | 11.3099 mL | 22.6198 mL | 56.5496 mL |
| 5 mM | 0.4524 mL | 2.2620 mL | 4.5240 mL | 11.3099 mL | |
| 10 mM | 0.2262 mL | 1.1310 mL | 2.2620 mL | 5.6550 mL | |
| 15 mM | 0.1508 mL | 0.7540 mL | 1.5080 mL | 3.7700 mL | |
| 20 mM | 0.1131 mL | 0.5655 mL | 1.1310 mL | 2.8275 mL | |
| 25 mM | 0.0905 mL | 0.4524 mL | 0.9048 mL | 2.2620 mL | |
| 30 mM | 0.0754 mL | 0.3770 mL | 0.7540 mL | 1.8850 mL | |
| 40 mM | 0.0565 mL | 0.2827 mL | 0.5655 mL | 1.4137 mL | |
| 50 mM | 0.0452 mL | 0.2262 mL | 0.4524 mL | 1.1310 mL | |
| 60 mM | 0.0377 mL | 0.1885 mL | 0.3770 mL | 0.9425 mL | |
| 80 mM | 0.0283 mL | 0.1414 mL | 0.2827 mL | 0.7069 mL | |
| 100 mM | 0.0226 mL | 0.1131 mL | 0.2262 mL | 0.5655 mL |
Chst15-IN-1 関連分類
HY-124704 関連分類
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