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Chst15-IN-1 

Cat. No.: HY-124704
Handling Instructions

Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair.

For research use only. We do not sell to patients.

Chst15-IN-1 Chemical Structure

Chst15-IN-1 Chemical Structure

CAS No. : 2158198-77-5

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Description

Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair[1].

IC50 & Target

Chst15[1]

In Vitro

Chst15-IN-1 (25 μM; 24 hours; Neu7 astrocytes) is selective for sulfotransferases over the myriad of reactive cysteine-containing proteins. Chst15-IN-1 (10 and 25 μM; Neu7 astrocytes) shows a significant dose dependent decrease in cell-surface CS-E expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chst15-IN-1 (3.0 mg/kg; i.v.) has a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 hours[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats
Dosage: 3.0 mg/kg (Pharmacokinetic Analysis)
Administration: I.v.
Result: Had a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 h.
Molecular Weight

442.09

Formula

C₁₇H₁₁BrCl₂N₂O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Chst15-IN-1
Cat. No.:
HY-124704
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