DTL - denticleless E3 ubiquitin protein ligase homolog Gene

Also Known as CDT2; RAMP; DCAF2; L2DTL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51514

About DTL

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,035,748-212,105,013 (from NCBI)

This gene has 6 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 9.8), bone marrow (RPKM 8.4) and 15 other tissues.

Summary

Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin Ligase complex and Cul4B-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DTL Products (3)

mRNA	Protein	Name
NM_001286229.2	NP_001273158.2	denticleless protein homolog isoform 2
NM_001286230.2	NP_001273159.2	denticleless protein homolog isoform 3
NM_016448.4	NP_057532.4	denticleless protein homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16949367	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	18794347	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	20129063	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	16949367	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	17085480	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16949367	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	16949367	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	20129063	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	18794347	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	17085480	GOA
involved in response to UV	IDA IDA: Inferred from direct assay	18794347	GOA
involved in translesion synthesis	IDA IDA: Inferred from direct assay	20129063	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	18794347	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	26431207	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul4-RING E3 ubiquitin ligase complex	IMP IMP: Inferred from mutant phenotype	16949367	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	17085480	GOA
part of Cul4B-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	18794347	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17106265	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17106265	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTL Protein Structure

WD40

0
200
400
600
730 a.a.

Protein Preferred Names	Protein Names
denticleless protein homolog	DDB1- and CUL4-associated factor 2

DTL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DTL	Q9NZJ0	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	17041588
Intra	DTL	Q9NZJ0	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	33961781
Intra	DTL	Q9NZJ0	DDB1	Homo sapiens	Q16531	Anti Bait CoIP	17041588
Intra	DTL	Q9NZJ0	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

DTL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82729	CDT2 Antibody (YA2474)	WB, IHC-P	Human
HY-P82729A	CDT2 Antibody (YA2474)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Myasthenic Syndrome, Congenital, 8	Congenital Myasthenic Syndrome 8 CMS8 Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects Cmsppd Myasthenic Syndrome, Congenital, 8, With Pre- And Postsynaptic Defects Congenital Myasthenic Syndrome Due To Agrin Deficiency Myasthenic Syndrome, Congenital, Due To Agrin Deficiency Congenital Myasthenic Syndrome 8 With Pre- And Postsynaptic Defects Myasthenic Syndrome, Congenital, Type 8, With Pre- And Postsynaptic Defects
Branchiootorenal Syndrome 1	Melnick-Fraser Syndrome BOR1 Branchiootorenal Dysplasia Branchiootorenal Syndrome 1, With Or Without Cataracts Bor Syndrome 1 Branchiootorenal Dysplasia 1 Branchio-Oto-Renal Dysplasia 1 Branchio-Oto-Renal Syndrome Type 1 Branchiootorenal Syndrome, With/Without Cataract, Type 1 Branchio-Oto-Renal Syndrome
Cockayne Syndrome A	Cockayne Syndrome Type 1 Cockayne Syndrome, Type A Cockayne Syndrome Type I CSA Cockayne Syndrome Classic Form Cockayne Syndrome Classical Cockayne Syndrome Type A Ckn1
Xeroderma Pigmentosum Group E	Xeroderma Pigmentosum, Group E Xeroderma Pigmentosum V Xp Group E Xp5 Xpe Xeroderma Pigmentosum, Complementation Group E
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS19108	Dtl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04034	DTL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14824	TNFSF13B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25598	Dtl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DTL	RGD	RGD:1310439
Bos taurus	DTL	VGNC	VGNC:28230
Canis familiaris	DTL	VGNC	VGNC:40113
Felis catus	DTL	VGNC	VGNC:61642
Macaca mulatta	DTL	VGNC	VGNC:71992
Mus musculus	DTL	MGD	MGI:1924093
Others	DTL	NCBI