TRMO - tRNA methyltransferase O Gene

Also Known as NAP1; HSPC219; C9orf156

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51531

About TRMO

This gene has 6 transcripts (splice variants) and 173 orthologues. Ubiquitous expression in thyroid (RPKM 2.2), lymph node (RPKM 1.5) and 25 other tissues.

Summary

Enables tRNA (adenine-N6-)-methyltransferase activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]

TRMO Products (7)

mRNA Protein Name
NM_001330725.2 NP_001317654.1 tRNA (adenine(37)-N6)-methyltransferase isoform 2
NM_001371657.1 NP_001358586.1 tRNA (adenine(37)-N6)-methyltransferase isoform 1
NM_001371658.1 NP_001358587.1 tRNA (adenine(37)-N6)-methyltransferase isoform 3
NM_001371659.1 NP_001358588.1 tRNA (adenine(37)-N6)-methyltransferase isoform 4
NM_001371660.1 NP_001358589.1 tRNA (adenine(37)-N6)-methyltransferase isoform 2
NM_001371661.1 NP_001358590.1 tRNA (adenine(37)-N6)-methyltransferase isoform 2
NM_016481.5 NP_057565.3 tRNA (adenine(37)-N6)-methyltransferase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity IDA
IDA: Inferred from direct assay
25063302 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA methylation IDA
IDA: Inferred from direct assay
25063302 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMO Protein Structure

UPF0066

UPF0066: Uncharacterised protein family UPF0066 (43 - 164)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
Protein Preferred Names Protein Names

tRNA (adenine(37)-N6)-methyltransferase

  • Nef (lentivirus myristoylated factor) associated protein 1

TRMO Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRMO Q9BU70 SPATC1L Homo sapiens Q9H0A9-2
Validated Y2H
32296183
Intra
TRMO Q9BU70 SPATC1L Homo sapiens Q9H0A9-2
Y2H Prey Pooling
32296183
Intra
TRMO Q9BU70 SPATC1L Homo sapiens Q9H0A9-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Arthrogryposis, Distal, Type 6

  • Distal Arthrogryposis Type 6

  • DA6

  • Arthrogryposis-Like Hand Anomaly-Sensorineural Deafness Syndrome

  • Arthrogryposis And Sensorineural Deafness

  • Familial Hand Abnormality And Sensori-Neural Deafness

  • Arthrogryposis-Like Hand Anomaly And Sensorineural Deafness

  • Arthrogryposis-Like Hand Anomaly-Sensorineural Hearing Loss Syndrome
Thiamine-Responsive Megaloblastic Anemia Syndrome

  • TRMA

  • Rogers Syndrome

  • Thiamine-Responsive Myelodysplasia

  • Thiamine-Responsive Anemia Syndrome

  • Thiamine Metabolism Dysfunction Syndrome 1

  • Thmd1

  • Megaloblastic Anemia, Thiamine-Responsive, With Diabetes Mellitus And Sensorineural Deafness

  • Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Deafness

  • Thiamine Responsive Megaloblastic Anemia Syndrome

  • Megaloblastic Anemia Thiamine-Responsive With Diabetes Mellitus And Sensorineural Deafness

  • Thiamine-Responsive Megaloblastic Anemia

  • Thiamine-Responsive Anaemia Syndrome

  • Thiamine-Responsive Megaloblastic Anaemia Syndrome

  • Thiamine-Responsive Megaloblastic Anaemia With Diabetes Mellitus And Sensorineural Deafness

  • Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Hearing Loss
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Galloway-Mowat Syndrome

  • Galloway Mowat Syndrome

  • Galloway Syndrome

  • Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

  • Microcephaly Nephrosis Syndrome

  • Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

  • Nephrosis Neuronal Dysmigration Syndrome

  • Microcephaly-Hiatus Hernia-Nephrotic Syndrome

  • Nephrosis-Neuronal Dysmigration Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15085 TRMO Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRMO VGNC VGNC:79907
Mus musculus TRMO MGD MGI:1922003
Bos taurus TRMO VGNC VGNC:36364
Rattus norvegicus TRMO RGD RGD:1305420
Felis catus TRMO VGNC VGNC:66564
Canis familiaris TRMO VGNC VGNC:47849