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PAK1IP1 - PAK1 interacting protein 1 Gene

Also Known as PIP1; MAK11; WDR84; hPIP1; bA421M1.5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55003

About PAK1IP1

Cytogenetic location: 6p24.2 Genomic coordinates (GRCh38): 6:10,690,865-10,709,782 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 198 orthologues and 26 paralogues. Ubiquitous expression in prostate (RPKM 23.6), appendix (RPKM 6.7) and 24 other tissues.

Summary

Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

PAK1IP1 Products (1)

mRNA	Protein	Name
NM_017906.3	NP_060376.2	p21-activated protein kinase-interacting protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25074804	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: Inferred from mutant phenotype	24120868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK1IP1 Protein Structure

WD40

0
100
200
300
392 a.a.

Protein Preferred Names	Protein Names
p21-activated protein kinase-interacting protein 1	PAK/PLC-interacting protein 1

PAK1IP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	26871637
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	26871637
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	26871637
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PAK1IP1	Q9NWT1	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	PAK1IP1	Q9NWT1	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Kidney Rhabdoid Cancer	Rhabdoid Tumor Of The Kidney Kidney Rhabdoid Tumor Renal Rhabdoid Tumor
Non-Syndromic X-Linked Intellectual Disability 30	Mrx30 Mrx47 X-Linked Mental Retardation 30/47 X-Linked Mental Retardation 47 Mental Retardation, X-Linked, Type 30/47
Orofacial Cleft 1	OFC1 Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 1 Orofacial Cleft, Nonsyndromic Ofc Cleft Lip/Palate, Nonsyndromic Orofacial Cleft-1 Nonsyndromic Cleft Lip With Or Without Cleft Palate 1 Nonsyndromic Cleft Lip Palate Otofaciocervical Syndrome 1
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09986	PAK1IP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PAK1IP1	VGNC	VGNC:75661
Felis catus	PAK1IP1	VGNC	VGNC:64026
Rattus norvegicus	PAK1IP1	RGD	RGD:1565353
Mus musculus	PAK1IP1	MGD	MGI:1915333
Canis familiaris	PAK1IP1	VGNC	VGNC:44244
Bos taurus	PAK1IP1	VGNC	VGNC:32555
Others	PAK1IP1	NCBI