PRELP - proline and arginine rich end leucine rich repeat protein Gene

Homo sapiens

Also known as MST161; SLRR2A; MSTP161

Gene ID: 5549 | Gene type: protein coding

About PRELP

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,475,806-203,491,352 (from NCBI)

This gene has 1 transcript (splice variant), 199 orthologues and 10 paralogues. Broad expression in ovary (RPKM 42.7), fat (RPKM 41.5) and 22 other tissues.

Summary

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

PRELP Products(2)

mRNA	Protein	Name
NM_002725.4	NP_002716.1	prolargin precursor
NM_201348.2	NP_958505.1	prolargin precursor

PRELP Protein Structure

LRRNT

LRR_8

LRR_1

0
100
200
300
382 a.a.

Protein Preferred Names

Protein Names

prolargin

55 kDa leucine-rich repeat protein of articular cartilage

Recombinant PRELP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75980	PRELP Protein, Human (HEK293)	P51888 (Q21-I382)	≥95%
HY-P75981	PRELP Protein, Human (HEK293, Fc)	P51888 (Q21-I382)	≥95%

Related Diseases

Diseases

Alias

Bladder Carcinoma In Situ

Carcinoma In Situ Of Bladder	Bladder Ca In Situ
Flat Cis Of The Urinary Bladder	Carcinoma In Situ Of Urinary Bladder

Retinitis Pigmentosa 23

RP23	Retinitis Pigmentosa-23
Retinitis Pigmentosa, Type 23	Rp23 Gene

Cornea Plana

Flat Cornea

Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant

Weissenbacher-Zweymuller Syndrome	Wzs
Pierre Robin Syndrome With Fetal Chondrodysplasia	OSMEDA
Weissenbacher-Zweymüller Syndrome	Heterozygous Osmed
Stickler Syndrome, Type 3	Osmed, Heterozygous
Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly	Stickler Syndrome, Type Iii, Formerly
Stl3, Formerly	Piere-Robin Syndrome
Pierre Robin Malformation	Heterozygous Otospondylomegaepiphyseal Dysplasia
Autosomal Dominant Otospondylomegaepiphyseal Dysplasia	Ad Osmed
Stickler Syndrome Type 3	Stickler Syndrome, Non-Ocular Type
Stickler-Like Syndrome	Stickler Syndrome 3
Stickler Syndrome Non-Ocular Type	Stickler Syndrome Type Iii
Stl3	Weissenbacher-Zweymueller Syndrome
Stickler Syndrome, Type Iii	Pierre Robin Syndrome
Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Stromal Dystrophy

Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease	2p21 Microdeletion Syndrome
HCS	Homozygous 2p16 Deletion Syndrome, Formerly
2p21 Deletion Syndrome	Del(2)(P21)
Monosomy 2p21	Atypical Hypotonia-Cystinuria Syndrome
Atypical Hcs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11082	PRELP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRELP	VGNC	VGNC:33309
Felis catus	PRELP	VGNC	VGNC:69040
Rattus norvegicus	PRELP	RGD	RGD:620226
Mus musculus	PRELP	MGD	MGI:2151110
Macaca mulatta	PRELP	VGNC	VGNC:76395
Canis familiaris	PRELP	VGNC	VGNC:44959
Others	PRELP	NCBI

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