PRELP - proline and arginine rich end leucine rich repeat protein Gene

Also Known as MST161; SLRR2A; MSTP161

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5549

About PRELP

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,475,806-203,491,352 (from NCBI)

This gene has 1 transcript (splice variant), 199 orthologues and 10 paralogues. Broad expression in ovary (RPKM 42.7), fat (RPKM 41.5) and 22 other tissues.

Summary

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I Collagen to basement membranes and type II Collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of Collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

PRELP Products (2)

mRNA Protein Name
NM_002725.4 NP_002716.1 prolargin precursor
NM_201348.2 NP_958505.1 prolargin precursor

PRELP Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (72 - 101)

LRR_8

LRR_8: Leucine rich repeat (102 - 162)

LRR_8

LRR_8: Leucine rich repeat (171 - 231)

LRR_8

LRR_8: Leucine rich repeat (245 - 303)

LRR_1

LRR_1: Leucine Rich Repeat (312 - 327)

(350 - 363)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
Protein Preferred Names Protein Names

prolargin

  • 55 kDa leucine-rich repeat protein of articular cartilage

Recombinant PRELP Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75980 PRELP Protein, Human (HEK293) P51888/NP_002716.1 (Q21-I382) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75981 PRELP Protein, Human (HEK293, Fc) P51888 (Q21-I382) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Bladder Carcinoma In Situ

  • Carcinoma In Situ Of Bladder

  • Bladder Ca In Situ

  • Flat Cis Of The Urinary Bladder

  • Carcinoma In Situ Of Urinary Bladder
Retinitis Pigmentosa 23

  • RP23

  • Retinitis Pigmentosa-23

  • Retinitis Pigmentosa, Type 23

  • Rp23 Gene
Cornea Plana

  • Flat Cornea
Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant

  • Weissenbacher-Zweymuller Syndrome

  • Wzs

  • Pierre Robin Syndrome With Fetal Chondrodysplasia

  • OSMEDA

  • Weissenbacher-Zweymüller Syndrome

  • Heterozygous Osmed

  • Stickler Syndrome, Type 3

  • Osmed, Heterozygous

  • Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly

  • Stickler Syndrome, Type Iii, Formerly

  • Stl3, Formerly

  • Piere-Robin Syndrome

  • Pierre Robin Malformation

  • Heterozygous Otospondylomegaepiphyseal Dysplasia

  • Autosomal Dominant Otospondylomegaepiphyseal Dysplasia

  • Ad Osmed

  • Stickler Syndrome Type 3

  • Stickler Syndrome, Non-Ocular Type

  • Stickler-Like Syndrome

  • Stickler Syndrome 3

  • Stickler Syndrome Non-Ocular Type

  • Stickler Syndrome Type Iii

  • Stl3

  • Weissenbacher-Zweymueller Syndrome

  • Stickler Syndrome, Type Iii

  • Pierre Robin Syndrome

  • Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Stromal Dystrophy
Hypotonia-Cystinuria Syndrome

  • Cystinuria With Mitochondrial Disease

  • 2p21 Microdeletion Syndrome

  • HCS

  • Homozygous 2p16 Deletion Syndrome, Formerly

  • 2p21 Deletion Syndrome

  • Del(2)(P21)

  • Monosomy 2p21

  • Atypical Hypotonia-Cystinuria Syndrome

  • Atypical Hcs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11082 PRELP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20086 Prelp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26589 Prelp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PRELP VGNC VGNC:33309
Felis catus PRELP VGNC VGNC:69040
Rattus norvegicus PRELP RGD RGD:620226
Mus musculus PRELP MGD MGI:2151110
Macaca mulatta PRELP VGNC VGNC:76395
Canis familiaris PRELP VGNC VGNC:44959
Others PRELP NCBI