PRELP Protein, Human (HEK293, Fc)
The PRELP protein may be an anchoring factor that plays a crucial role in connecting the basement membrane and connective tissue, contributing to structural integrity. Its interaction with the heparan sulfate proteoglycan perlecan and type I and type II collagen emphasizes its versatile binding ability. PRELP Protein, Human (HEK293, Fc) is the recombinant human-derived PRELP protein, expressed by HEK293 , with N-mFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The PRELP protein may be an anchoring factor that plays a crucial role in connecting the basement membrane and connective tissue, contributing to structural integrity. Its interaction with the heparan sulfate proteoglycan perlecan and type I and type II collagen emphasizes its versatile binding ability. PRELP Protein, Human (HEK293, Fc) is the recombinant human-derived PRELP protein, expressed by HEK293 , with N-mFc labeled tag.
Background
PRELP Protein emerges as a potential anchoring factor linking basement membranes to the underlying connective tissue, suggesting a crucial role in structural integrity. This function implies its involvement in maintaining the stability and organization of extracellular matrices. PRELP specifically interacts with the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type II, underscoring its versatile binding capabilities and its significance in mediating molecular connections within the extracellular environment. The protein's dual ability to anchor to perlecan and collagens hints at its role in orchestrating the intricate composition of basement membranes, reflecting its potential contributions to tissue architecture and homeostasis. Further exploration of PRELP's interactions and functions may unveil its specific mechanisms in basement membrane anchoring and provide insights into its broader implications in connective tissue biology.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-mFc
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Accession
P51888 (Q21-I382)
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Molecular Construction
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N-term
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mFc
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PRELP (Q21-I382)
Accession # P51888 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
PRELP; 55 KDa Leucine-Rich Repeat Protein Of Articular Cartilage; Proline And Arginine Rich End Leucine Rich Repeat Protein; Proline Arginine-Rich End Leucine-Rich Repeat Protein; Prolargin; PRELP Protein; SLRR2A; MSTP161; Proline-Arginine-Rich End Leucin
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AA Sequence
QPTRRPRPGTGPGRRPRPRPRPTPSFPQPDEPAEPTDLPPPLPPGPPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPVIPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRGLPKNSFNISNLLVLHLSHNRISSVPAINNRLEHLYLNNNSIEKINGTQICPNDLVAFHDFSSDLENVPHLRYLRLDGNYLKPPIPLDLMMCFRLLQSVVI
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Predicted Molecular Mass
68.3 kDa
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Molecular Weight
Approximately 80-90 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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