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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
55565
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "55565" in MCE Product Catalog:
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7 Publications Verification
Cat. No.: HY-19635A
CAS No.: 2319590-15-1
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
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Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
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6 Cited Publications
Synonyms: DS 5565 besylate
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Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.
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Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor .
Cat. No.: HY-18200
CAS No.: 751475-53-3
Synonyms: E5555; ER-172594-00
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Atopaxar (E5555) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar, an antiplatelet agent, interferes with platelet signaling. Atopaxar can be used for the research of atherothrombotic disease .
Cat. No.: HY-W010869
CAS No.: 172854-55-6
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GR 55562 hydrochloride is a selective 5-HT1B receptor antagonist. GR 55562 hydrochloride can be used for the research of nerve disease .
Cat. No.: HY-P4325
CAS No.: 109528-50-9
Cat. No.: HY-12650S1
Synonyms: DS5565-d4
Cat. No.: HY-101367
CAS No.: 159533-26-3
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GR 55562 is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease .
Cat. No.: HY-18200B
CAS No.: 474550-69-1
Synonyms: E5555 hydrobromide; ER 172594-06
Research Areas:
Atopaxar (E5555) hydrobromide is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar hydrobromide, an antiplatelet agent, interferes with platelet signaling. Atopaxar hydrobromide can be used for the research of atherothrombotic disease .
Cat. No.: HY-12650S
Synonyms: DS5565-13C2,d1 (Mixture of Diastereomers)
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GR 55562 dihydrochloride is a selective 5-HT1B receptor antagonist. GR 55562 dihydrochloride can be used for the research of nerve disease .
Cat. No.: HY-12650A
CAS No.: 1138244-97-9
Synonyms: (rel)-DS5565
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(rel)-Mirogabalin ((rel)-DS5565) is a voltage-dependent calcium channel inhibitor that acts on the α2δ-1 subunit .
Cat. No.: HY-12650R
CAS No.: 1138245-13-2
Synonyms: DS5565 (Standard)
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Mirogabalin (Standard) is the analytical standard of Mirogabalin. This product is intended for research and analytical applications. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
Cat. No.: HY-P4795
CAS No.: 125441-01-2
Cat. No.: HY-18200A
CAS No.: 474544-83-7
Synonyms: E5555 hydrochloride; ER-172594-00 hydrochloride
Research Areas:
Atopaxar hydrochloride (E5555 hydrochloride) is the hydrochloride salt form of Atopaxar (HY-18200). Atopaxar hydrochloride is an orally active, selective and reversible antagonist for thrombin receptor protease-activated receptor-1 (PAR-1). Atopaxar hydrochloride is the inhibitor for Janus kinase 1 (JAK1) and JAK2, which inhibits the JAK-STAT with EC50 of 5.90 μM in A549. Atopaxar hydrochloride inhibits the cell viability of A549 (IC50=7.02 μM), arrests the cell cycle at G1 phase and induces apoptosis. Atopaxar hydrochloride exhibits antiplatelet and antitumor activities. Atopaxar hydrochloride can be used for the research of atherothrombotic disease .
Cat. No.: HY-108006R
CAS No.: 1138245-21-2
Synonyms: DS 5565 besylate (Standard)
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Research Areas:
Mirogabalin besylate (Standard) is the analytical standard of Mirogabalin besylate (HY-108006). This product is intended for research and analytical applications. Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
