TASP1 - taspase 1 Gene

Also Known as SULEHS; C20orf13; dJ585I14.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55617

About TASP1

Cytogenetic location: 20p12.1 Genomic coordinates (GRCh38): 20:13,104,772-13,638,932 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 2.9), testis (RPKM 2.2) and 25 other tissues.

Summary

This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

TASP1 Products (4)

mRNA	Protein	Name
NM_001323602.2	NP_001310531.1	threonine aspartase 1 isoform 2
NM_001323603.2	NP_001310532.1	threonine aspartase 1 isoform 3
NM_001323604.2	NP_001310533.1	threonine aspartase 1 isoform 3
NM_017714.3	NP_060184.2	threonine aspartase 1 isoform 1 precursor

TASP1 Protein Structure

Asparaginase_2

0
100
200
300
400
420 a.a.

Protein Preferred Names	Protein Names
threonine aspartase 1

TASP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TASP1	Q9H6P5	TASP1	Homo sapiens	Q9H6P5	Light Scattering	16216576
Intra	TASP1	Q9H6P5	TASP1	Homo sapiens	Q9H6P5	GMS	16216576
Intra	TASP1	Q9H6P5	TASP1	Homo sapiens	Q9H6P5	Pull Down	16216576
Intra	TASP1	Q9H6P5	TASP1	Homo sapiens	Q9H6P5	X-Ray Diffraction	16216576

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Suleiman-El-Hattab Syndrome	SULEHS
Balantidiasis	Balantidiosis Human Balantidiasis B Coli Infection Balantidium Coli Infection Large-Intestinal Infection With Balantidium Coli Ciliary Dysentery
Bjornstad Syndrome	BJS Pili Torti And Nerve Deafness Ptd Pili Torti-Deafness Syndrome Deafness-Pili Torti-Hypogonadism Syndrome Deafness And Pili Torti, Bjornstad Type Pili Torti-Sensorineural Hearing Loss Björnstad Syndrome Ptnd Hearing Loss-Pili Torti-Hypogonadism Syndrome Bjoernstad Syndrome
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Kabuki Syndrome 1	Kabuki Syndrome Niikawa-Kuroki Syndrome Kabuki Make-Up Syndrome Kms KABUK1 Kabuki Make Up Syndrome Nks Kabuki Makeup Syndrome Kabuki Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11596	NOTA-Asp2-αvβ6L		/	Unkown
HY-RS14224	TASP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TASP1	MGD	MGI:1923062
Rattus norvegicus	TASP1	RGD	RGD:1308591
Bos taurus	TASP1	VGNC	VGNC:35615
Macaca mulatta	TASP1	VGNC	VGNC:78129
Canis familiaris	TASP1	VGNC	VGNC:47122
Felis catus	TASP1	VGNC	VGNC:65964
Others	TASP1	NCBI