SLC30A6 - solute carrier family 30 member 6 Gene

Also Known as ZNT6; MST103; MSTP103

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 55676

About SLC30A6

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:32,165,864-32,224,379 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 4.9), urinary bladder (RPKM 4.1) and 25 other tissues.

Summary

This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016]

SLC30A6 Products (8)

mRNA	Protein	Name
NM_001193513.3	NP_001180442.1	zinc transporter 6 isoform 1
NM_001193514.3	NP_001180443.1	zinc transporter 6 isoform 3
NM_001193515.3	NP_001180444.1	zinc transporter 6 isoform 4
NM_001330476.2	NP_001317405.1	zinc transporter 6 isoform 5
NM_001330477.2	NP_001317406.1	zinc transporter 6 isoform 6
NM_001330478.2	NP_001317407.1	zinc transporter 6 isoform 6
NM_001330479.2	NP_001317408.1	zinc transporter 6 isoform 7
NM_017964.5	NP_060434.2	zinc transporter 6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	15994300	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	15994300	GOA
NOT enables zinc:proton antiporter activity	IDA IDA: Inferred from direct assay	19366695	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in regulation of zinc ion transport	IDA IDA: Inferred from direct assay	19366695	GOA
involved in zinc ion import into Golgi lumen	IDA IDA: Inferred from direct assay	15994300	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17349999	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	19366695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A6 Protein Structure

Cation_efflux

0
100
200
300
400
461 a.a.

Protein Preferred Names	Protein Names
zinc transporter 6	solute carrier family 30 (zinc transporter), member 6

SLC30A6 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SLC30A6	Q6NXT4	SLC30A5	Homo sapiens	Q8TAD4	Anti Tag CoIP	19759014
Intra	SLC30A6	Q6NXT4	SLC30A5	Homo sapiens	Q8TAD4	IF	19759014

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Hypermanganesemia With Dystonia 1	Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis HMNDYT1 Hmdpc Hypermanganesemia With Dystonia Polycythemia And Cirrhosis Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Hypermanganesemia With Dystonia 2	HMNDYT2 Dystonia-Parkinsonism-Hypermanganesemia Syndrome Hypermanganesemia With Dystonia, Type 2
Spastic Paraplegia 4, Autosomal Dominant	SPG4 Hereditary Spastic Paraplegia 4 Fsp2 Autosomal Dominant Spastic Paraplegia Type 4 Familial Spastic Paraplegia, Autosomal Dominant, 2 Autosomal Dominant Spastic Paraplegia 4 Familial Spastic Paraplegia Autosomal Dominant 2 Paraplegia, Spastic, Autosomal Dominant, Type 4
Hypermanganesemia With Dystonia	Familial Manganese-Induced Neurotoxicity Hmndyt
Mucinous Stomach Adenocarcinoma	Mucinous Adenocarcinoma Of The Stomach Mucinous Gastric Adenocarcinoma
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS13184	SLC30A6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	SLC30A6	MGD	MGI:2386741
Macaca mulatta	SLC30A6	VGNC	VGNC:77513
Rattus norvegicus	SLC30A6	RGD	RGD:1309250
Felis catus	SLC30A6	VGNC	VGNC:65312
Bos taurus	SLC30A6	VGNC	VGNC:34810
Canis familiaris	SLC30A6	VGNC	VGNC:46351
Others	SLC30A6	NCBI