SLC30A5 - solute carrier family 30 member 5 Gene

Also Known as ZNT5; ZTL1; ZNTL1; ZnT-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64924

About SLC30A5

Cytogenetic location: 5q13.1-q13.2 Genomic coordinates (GRCh38): 5:69,094,014-69,131,069 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 17.6), gall bladder (RPKM 11.0) and 25 other tissues.

Summary

This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]

SLC30A5 Products (3)

mRNA	Protein	Name
NM_001251969.2	NP_001238898.1	zinc transporter 5 isoform 3
NM_022902.5	NP_075053.2	zinc transporter 5 isoform 1
NM_024055.5	NP_076960.1	zinc transporter 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables cadmium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	22529353	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15994300	GOA
enables zinc efflux transmembrane transporter activity	IDA IDA: Inferred from direct assay	17355957	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	11904301	GOA
enables zinc:proton antiporter activity	IDA IDA: Inferred from direct assay	19366695	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of positive effect GPI anchor biosynthetic process	IMP IMP: Inferred from mutant phenotype	35525268	GOA
acts upstream of or within cobalt ion transport	IDA IDA: Inferred from direct assay	11937503	GOA
involved in intracellular zinc ion homeostasis	IDA IDA: Inferred from direct assay	11937503	GOA
involved in response to zinc ion	IDA IDA: Inferred from direct assay	11937503	GOA
involved in zinc ion import across plasma membrane	IDA IDA: Inferred from direct assay	17355957	GOA
involved in zinc ion import into Golgi lumen	IDA IDA: Inferred from direct assay	15525635	GOA
involved in zinc ion import into organelle	IDA IDA: Inferred from direct assay	11904301	GOA
involved in zinc ion import into organelle	IMP IMP: Inferred from mutant phenotype	35525268	GOA
involved in zinc ion transport	IDA IDA: Inferred from direct assay	11937503	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in ER to Golgi transport vesicle membrane	IDA IDA: Inferred from direct assay	15525635	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17349999	GOA
located in Golgi cis cisterna membrane	IDA IDA: Inferred from direct assay	11904301	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	21887337	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11937503	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21887337	GOA
located in membrane	IDA IDA: Inferred from direct assay	11904301	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17355957	GOA
located in secretory granule membrane	IDA IDA: Inferred from direct assay	11904301	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	19366695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A5 Protein Structure

Cation_efflux

0
200
400
600
765 a.a.

Protein Preferred Names	Protein Names
zinc transporter 5	solute carrier family 30 (zinc transporter), member 5

SLC30A5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC30A5	Q8TAD4	SLC30A6	Homo sapiens	Q6NXT4	BiFC	25657003
Intra	SLC30A5	Q8TAD4	SLC30A6	Homo sapiens	Q6NXT4	Confocal	15994300
Intra	SLC30A5	Q8TAD4	SLC30A6	Homo sapiens	Q6NXT4	Anti Tag CoIP	15994300
Intra	SLC30A5	Q8TAD4	SLC30A6	Homo sapiens	Q6NXT4	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Left Ventricular Noncompaction	Noncompaction Cardiomyopathy Left Ventricular Hypertrabeculation Lvnc Spongy Myocardium Isolated Noncompaction Of The Ventricular Myocardium Left Ventricular Myocardial Noncompaction Cardiomyopathy Fetal Myocardium Honeycomb Myocardium Hypertrabeculation Syndrome Left Ventricular Non-Compaction Lvht Non-Compaction Of The Left Ventricular Myocardium Ventricular Noncompaction, Left Non-Compaction Cardiomyopathy
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Hypermanganesemia With Dystonia 1	Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis HMNDYT1 Hmdpc Hypermanganesemia With Dystonia Polycythemia And Cirrhosis Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome
Hypermanganesemia With Dystonia 2	HMNDYT2 Dystonia-Parkinsonism-Hypermanganesemia Syndrome Hypermanganesemia With Dystonia, Type 2
Hypermanganesemia With Dystonia	Familial Manganese-Induced Neurotoxicity Hmndyt
Mucinous Stomach Adenocarcinoma	Mucinous Adenocarcinoma Of The Stomach Mucinous Gastric Adenocarcinoma
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13183	SLC30A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC30A5	RGD	RGD:1306931
Canis familiaris	SLC30A5	VGNC	VGNC:46350
Bos taurus	SLC30A5	VGNC	VGNC:34809
Mus musculus	SLC30A5	MGD	MGI:1916298
Felis catus	SLC30A5	VGNC	VGNC:65311
Macaca mulatta	SLC30A5	VGNC	VGNC:77512
Others	SLC30A5	NCBI