TSR1 - TSR1 ribosome maturation factor Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55720

About TSR1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,322,396-2,336,457 (from NCBI)

This gene has 5 transcripts (splice variants), 224 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.8), esophagus (RPKM 10.6) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Predicted to be part of preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]

TSR1 Products (1)

mRNA Protein Name
NM_018128.5 NP_060598.3 pre-rRNA-processing protein TSR1 homolog

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSR1 Protein Structure

AARP2CN

AARP2CN: AARP2CN (NUC121) domain (228 - 309)

RIBIOP_C

RIBIOP_C: 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal (487 - 773)

  • 0
  • 200
  • 400
  • 600
  • 804 a.a.
Protein Preferred Names Protein Names

pre-rRNA-processing protein TSR1 homolog

TSR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TSR1 Q2NL82 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
TSR1 Q2NL82 RHBDD2 Homo sapiens Q6NTF9-3
Validated Y2H
32296183
Intra
TSR1 Q2NL82 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra
TSR1 Q2NL82 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
TSR1 Q2NL82 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
TSR1 Q2NL82 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epithelial Malignant Thymoma

  • Squamoid Thymoma

  • Thymoma, Epithelial

  • Well Differentiated Thymic Carcinoma

  • Thymoma, Type B3
Dendritic Cell Thymoma

  • Epithelioid Thymoma

  • Type B Thymoma
Geleophysic Dysplasia 3

  • GPHYSD3
Otomycosis

  • Singapore Ear
Geleophysic Dysplasia 2

  • GPHYSD2

  • Geleophysic Dwarfism

  • Dysplasia, Geleophysic, Type 2

  • Geleophysic Dysplasia
Geleophysic Dysplasia 1

  • GPHYSD1

  • Geleophysic Dwarfism

  • Geleophysic Dysplasia
Sick Building Syndrome
Geleophysic Dysplasia

  • Geleophysic Dwarfism

  • Gphysd
Peters-Plus Syndrome

  • Krause-Kivlin Syndrome

  • Peters Plus Syndrome

  • Peters Anomaly

  • Irido-Corneo-Trabecular Dysgenesis

  • PTRPLS

  • Peters Anomaly With Short-Limb Dwarfism

  • Peters Anomaly-Short Limb Dwarfism Syndrome

  • Peters Anomaly With Short Limb Dwarfism

  • Peters Congenital Glaucoma

  • Krause-Van Schooneveld-Kivlin Syndrome

  • Peters' Plus Syndrome

  • Peters'-Plus Syndrome

  • Anomaly Peters
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15184 TSR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18050 Tsr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24524 Tsr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TSR1 VGNC VGNC:36447
Rattus norvegicus TSR1 RGD RGD:2322150
Mus musculus TSR1 MGD MGI:2144566
Felis catus TSR1 VGNC VGNC:97669
Macaca mulatta TSR1 VGNC VGNC:79512
Others TSR1 NCBI