ADCY10 - adenylate cyclase 10 Gene

Also Known as SAC; HCA2; SACI; Sacy; hsAC; HEL-S-7a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55811

About ADCY10

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:167,809,386-167,914,134 (from NCBI)

This gene has 5 transcripts (splice variants), 155 orthologues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 5.6).

Summary

The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

ADCY10 Products (3)

mRNA	Protein	Name
NM_001167749.3	NP_001161221.1	adenylate cyclase type 10 isoform 2
NM_001297772.2	NP_001284701.1	adenylate cyclase type 10 isoform 3
NM_018417.6	NP_060887.2	adenylate cyclase type 10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables adenylate cyclase activity	IDA IDA: Inferred from direct assay	12609998	GOA
enables bicarbonate binding	IDA IDA: Inferred from direct assay	24567411	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cAMP biosynthetic process	IDA IDA: Inferred from direct assay	12609998	GOA
involved in epithelial cilium movement involved in extracellular fluid movement	IMP IMP: Inferred from mutant phenotype	17591988	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with microtubule cytoskeleton	IDA IDA: Inferred from direct assay	15659711	GOA
colocalizes with motile cilium	IDA IDA: Inferred from direct assay	17591988	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15659711	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15659711	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADCY10 Protein Structure

Guanylate_cyc

0
300
600
900
1200
1500
1610 a.a.

Protein Preferred Names	Protein Names
adenylate cyclase type 10	3',5'-cyclic AMP synthetase

Related Diseases

Diseases	Alias
Hypercalciuria, Absorptive, 2	HCA2 Hypercalciuria, Absorptive, Susceptibility To Hypercalciuria, Absorptive Familial Idiopathic Hypercalciuria Hypercalciuria, Familial Idiopathic Hypercalciuria Absorptive 2 Hypercalciuria Familial Idiopathic Hypercalciuria, Absorptive, Type 2 Hypercalciuria
Idiopathic Hypercalciuria
Platelet Adenylate Cyclase Activity
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Pertussis	Whooping Cough Bordetella Infections Bordetella Infection Bordetella Pertussis Infection Wc - Whooping Cough Whooping Cough Due To Unspecified Organism Bordetellosis Tussis Convulsiva Whooping Cough, Unspecified Organism Wc - [Whooping Cough] Whooping Cough Due To B. Parapertussis Infection Due To Bordetella Parapertussis
Pseudohypoparathyroidism, Type Ii	Pseudohypoparathyroidism Type 2 PHP2 Php Ii
Pseudohypoparathyroidism	Familial Pseudohypoparathyroidism Parathyroid Hormone Resistant Hypoparathyroidism Php - [Pseudohypoparathyroidism] Constitutional Chronic Hypocalcaemia
Morphine Dependence
Anthrax Disease	Anthrax Ragpicker'S Disease Black Baine Malignant Edema Malignant Pustule Siberian Plague Wool Sorter'S Disease Gas Gangrene Cutaneous Anthrax Anthrax Infection Splenic Fever
Orofaciodigital Syndrome Iv	OFD4 Baraitser-Burn Syndrome Orofaciodigital Syndrome 4 Ofd Syndrome With Tibial Defects Mohr-Majewski Syndrome Ofds Iv Oral-Facial-Digital Syndrome, Type Iv Ofd Syndrome, Baraitser-Burn Type Oral-Facial-Digital Syndrome Type 4 Ofd Syndrome 4 Ofds 4 Oral Facial Digital Syndrome 4 Oral Facial Digital Syndrome Type 4 Orofaciodigital Syndrome With Tibial Dysplasia Orofaciodigital Syndrome Type 4 Ofd Syndrome Baraitser-Burn Type Oral-Facial-Digital Syndrome 4 Orofaciodigital Syndrome, Type Iv
Juvenile Dermatitis Herpetiformis
Shipyard Eye	Epidemic Keratoconjunctivitis Ekc
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Korean Hemorrhagic Fever	Hemorrhagic Fever With Renal Syndrome
Inflammatory Bowel Disease 16	IBD16 Inflammatory Bowel Disease 16, Susceptibility To
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Hypermethioninemia Due To Adenosine Kinase Deficiency	Adk Hypermethioninemia Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency Hypermethioninemia Encephalopathy Due To Adk Deficiency Mrt8 Mental Retardation, Autosomal Recessive 8, Formerly Mrt8, Formerly HMAKD Mental Retardation, Autosomal Recessive 8
Hemophagocytic Lymphohistiocytosis, Familial, 3	Familial Hemophagocytic Lymphohistiocytosis 3 FHL3 Hplh3 Hlh3 Lymphohistiocytosis, Hemophagocytic, Familial, Type 3
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132298	TDI-10229	Inhibitor	99.00%	Unkown
HY-151798	TDI-11861	Inhibitor	99.35%	Unkown
HY-RS00327	ADCY10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18004	Adcy10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24476	Adcy10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADCY10	RGD	RGD:708450
Mus musculus	ADCY10	MGD	MGI:2660854
Felis catus	ADCY10	VGNC	VGNC:59614
Bos taurus	ADCY10	VGNC	VGNC:53843
Canis familiaris	ADCY10	VGNC	VGNC:53325
Macaca mulatta	ADCY10	VGNC	VGNC:69491
Others	ADCY10	NCBI