RALGDS - ral guanine nucleotide dissociation stimulator Gene
Also Known as RGF; RGDS; RalGEF
Species: Homo sapiens
About RALGDS
This gene has 15 transcripts (splice variants), 329 orthologues, 24 paralogues and is associated with 69 phenotypes. Ubiquitous expression in skin (RPKM 22.8), gall bladder (RPKM 22.0) and 25 other tissues.
Summary
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
RALGDS Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001042368.3 | NP_001035827.1 | ral guanine nucleotide dissociation stimulator isoform 2 |
| NM_001271774.2 | NP_001258703.1 | ral guanine nucleotide dissociation stimulator isoform 3 |
| NM_001271775.2 | NP_001258704.1 | ral guanine nucleotide dissociation stimulator isoform 4 |
| NM_001271776.2 | NP_001258705.1 | ral guanine nucleotide dissociation stimulator isoform 5 |
| NM_006266.4 | NP_006257.1 | ral guanine nucleotide dissociation stimulator isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables GTPase regulator activity |
IDA
IDA: Inferred from direct assay
|
7972015 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
20936779 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in brush border |
IDA
IDA: Inferred from direct assay
|
22797597 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
22797597 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
22797597 | GOA |
RALGDS Protein Structure
RasGEF_N: RasGEF N-terminal motif (115 - 225)
RasGEF: RasGEF domain (385 - 597)
RA: Ras association (RalGDS/AF-6) domain (798 - 884)
- 0
- 200
- 400
- 600
- 800
- 914 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ral guanine nucleotide dissociation stimulator |
|
RALGDS Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
RALGDS | Q12967 | HRAS | Homo sapiens | P01112 | 25241761 | |
|
Intra
|
RALGDS | Q12967 | RAP1B | Homo sapiens | P61224 | 22705156 | |
|
Intra
|
RALGDS | Q12967 | RAP1B | Homo sapiens | P61224 | 21988832 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Malignant Otitis Externa |
|
|
| Rasopathy |
|
|
| Cardiofaciocutaneous Syndrome 1 |
|
|
| Noonan Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | RALGDS | RGD | RGD:3533 |
| Mus musculus | RALGDS | MGD | MGI:107485 |
| Others | RALGDS | NCBI |