RAP1B - RAP1B, member of RAS oncogene family Gene

Also Known as K-REV; RAL1B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5908

About RAP1B

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:68,610,899-68,671,901 (from NCBI)

This gene has 33 transcripts (splice variants), 190 orthologues, 35 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 83.8), appendix (RPKM 79.8) and 25 other tissues.

Summary

This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]

RAP1B Products (6)

mRNA Protein Name
NM_001010942.3 NP_001010942.1 ras-related protein Rap-1b isoform 1 precursor
NM_001251917.2 NP_001238846.1 ras-related protein Rap-1b isoform 2
NM_001251918.2 NP_001238847.1 ras-related protein Rap-1b isoform 2
NM_001251921.2 NP_001238850.1 ras-related protein Rap-1b isoform 3
NM_001251922.2 NP_001238851.1 ras-related protein Rap-1b isoform 4
NM_015646.6 NP_056461.1 ras-related protein Rap-1b isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
18309292 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
18309292 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
18309292 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16452984 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
23209302 GOA
Biological Process GO Annotation Evidence References Source
involved in Rap protein signal transduction IMP
IMP: Inferred from mutant phenotype
21840392 GOA
involved in cellular response to cAMP IDA
IDA: Inferred from direct assay
21840392 GOA
involved in establishment of endothelial barrier IMP
IMP: Inferred from mutant phenotype
21840392 GOA
NOT involved in microvillus assembly IMP
IMP: Inferred from mutant phenotype
22797597 GOA
involved in positive regulation of integrin activation IMP
IMP: Inferred from mutant phenotype
19461049 GOA
involved in regulation of cell junction assembly IMP
IMP: Inferred from mutant phenotype
21840392 GOA
involved in regulation of establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
20332120 GOA
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
20332120 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18582561 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
14741744 GOA
NOT located in membrane raft IDA
IDA: Inferred from direct assay
18582561 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP1B Protein Structure

Ras

Ras: Ras family (5 - 166)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

ras-related protein Rap-1b

  • GTP-binding protein smg p21B

RAP1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAP1B P61224 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
RAP1B P61224 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
RAP1B P61224 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
RAP1B P61224 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
RAP1B P61224 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
RAP1B P61224 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
RAP1B P61224 RALGDS Homo sapiens Q12967-6
Validated Y2H
32296183
Intra
RAP1B P61224 RASSF5 Homo sapiens Q8WWW0
Y2H Prey Pooling
25416956
Intra
RAP1B P61224 RASSF5 Homo sapiens Q8WWW0
Validated Y2H
25416956
Intra
RAP1B P61224 RASSF5 Homo sapiens Q8WWW0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

RAP1B Antibodies

Cat. No. Product Name Application Reactivity
HY-P82079 RAP1A+RAP1B Antibody (YA1824) WB, IP, FC Human, Mouse, Rat
HY-P82079A RAP1A+RAP1B Antibody (YA1824)(PBS only) WB, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Cerebral Cavernous Malformations

  • Cerebral Cavernous Malformation

  • Cavernous Malformations Of Cns And Retina

  • Cerebral Cavernous Malformation 1

  • Cavernous Angiomatous Malformations

  • Cerebral Capillary Malformations

  • CCM

  • Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

  • Familial Cavernous Angioma

  • Cavernous Angioma

  • Familial Cerebral Cavernous Malformation

  • Cerebral Cavernous Malformations 1

  • Cavernous Angioma, Familial

  • Cam

  • Cerebral Cavernous Malformations-1

  • Cavernoma

  • Central Nervous System Cavernous Hemangioma

  • Cerebral Cavernous Hemangioma

  • Familial Cavernous Hemangioma

  • Familial Cavernous Malformation

  • Familial Cerebral Cavernous Angioma

  • Intracerebral Cavernous Hemangioma

  • CCM1

  • Cavernous Hemangioma Of The Brain

  • Cerebral Cavernoma

  • Cerebral Cavernous Malformations, Type 1

  • Hemangioma, Cavernous, Central Nervous System

  • Hemangioma, Cavernous

  • Angioma, Cavernous
Cervical Non-Keratinizing Squamous Cell Carcinoma
Cerebrocostomandibular Syndrome

  • Cerebro-Costo-Mandibular Syndrome

  • CCMS

  • Rib Gap Defects With Micrognathia

  • Ccm Syndrome
Cavernous Hemangioma

  • Hemangioma, Cavernous

  • Cavernoma

  • Cavernous Haemangioma
Babesiosis

  • Babesiasis

  • Infection By Babesia

  • Piroplasmosis

  • Human Babesiosis

  • Babesia Parasite Infection

  • Piroplasma Infection
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180801 E8431 97.34% Unkown
HY-RS16301 Rap1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11653 RAP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29280 Rap1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RAP1B RGD RGD:620577
Mus musculus RAP1B MGD MGI:894315
Canis familiaris RAP1B VGNC VGNC:108214
Others RAP1B NCBI