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RNASE2 - ribonuclease A family member 2 Gene

Also Known as EDN; RAF3; RNS2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6036

About RNASE2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,955,487-20,956,436 (from NCBI)

This gene has 1 transcript (splice variant), 128 orthologues and 12 paralogues. Restricted expression toward bone marrow (RPKM 516.0).

Summary

The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

RNASE2 Products (1)

mRNA	Protein	Name
NM_002934.3	NP_002925.1	non-secretory ribonuclease precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables RNA nuclease activity	IDA IDA: Inferred from direct assay	9826755	GOA
NOT enables lipopolysaccharide binding	IMP IMP: Inferred from mutant phenotype	23992292	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chemotaxis	IDA IDA: Inferred from direct assay	12855582	GOA
NOT involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	23992292	GOA
NOT involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	23992292	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	9826755	GOA
NOT involved in induction of bacterial agglutination	IMP IMP: Inferred from mutant phenotype	23992292	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNASE2 Protein Structure

RnaseA

0
100
161 a.a.

Protein Preferred Names	Protein Names
non-secretory ribonuclease	RNase 2

RNASE2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNASE2	P10153	DLG2	Homo sapiens	Q15700	Validated Y2H	32296183
Intra	RNASE2	P10153	DLG2	Homo sapiens	Q15700	Y2H Array	32296183
Intra	RNASE2	P10153	DLG2	Homo sapiens	Q15700	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pulmonary Eosinophilia	Asthmatic Pulmonary Eosinophilia Eosinophilic Lung Infiltrate Weingarten'S Syndrome
Dermatitis, Atopic, 8	ATOD8 Atopic Dermatitis 8 Dermatitis, Atopic, Severity Of Dermatitis, Atopic, Susceptibility To, 8 Dermatitis, Atopic 8
Esophagitis, Eosinophilic, 1	Eosinophilic Esophagitis EOE1 Esophagitis, Eosinophilic Ee
Chronic Eosinophilic Pneumonia	Carrington Syndrome Idiopathic Chronic Eosinophilic Pneumonia Cryptogenic Pulmonary Eosinophilia Idiopathic Eosinophilic Chronic Pneumopathy Carrington'S Disease Carrington'S Pulmonary Eosinophilia Chronic Idiopathic Eosinophilic Pneumonia Eosinophilic Idiopathic Chronic Pneumopathy Eosinophilic Pneumonia Chronic
Loeffler Endocarditis	Eosinophilic Endomyocardial Disease Eosinophilic Endocarditis Loeffler'S Endocarditis Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Endomyocardial Fibrosis	Becker'S Disease Obscure African Cardiomyopathy African Endomyocardial Fibrosis Endomyocardial Sclerosis EMF Becker Muscular Dystrophy
Eosinophilic Gastroenteritis	Eosinophilic Enteritis Ege Eosinophilic Gastroenterocolitis Eosinophilic Esophagitis Eosinophilic Gastritis Eosinophilic Gastroenteropathy Gastroenteritis, Eosinophilic Eosinophilic Enteropathy
Eosinophilic Gastritis	Eosinophilic Enteropathy
Spondyloepiphyseal Dysplasia, Nishimura Type	SEDN Spondyloepiphyseal Dysplasia Nishimura Type
Eosinophilia-Myalgia Syndrome	Eosinophilia Myalgia Syndrome Ems L-Tryptophan Induced Ems Severe Muscle Pain And Abnormally High Eosinophils Syndrome With Inflammatory And Autoimmune Components That Affect The Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, And Heart
Disseminated Eosinophilic Collagen Disease
Subdural Empyema	Empyema, Subdural Subdural Abscess
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Acute Asthma
Nasal Cavity Disease	Disorder Of Nasal Cavity
Nose Disease	Nose Diseases Disorder Of The Nose Nasal Disorder Abnormality Of The Nose
Respiratory Allergy	Airway Allergy
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12019	RNASE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26697	Rnase2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNASE2	RGD	RGD:1359432
Others	RNASE2	NCBI