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RPS21 - ribosomal protein S21 Gene

Also Known as S21; HLDF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6227

About RPS21

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,387,103-62,388,520 (from NCBI)

This gene has 5 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in ovary (RPKM 530.1), bone marrow (RPKM 407.8) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS21 Products (1)

mRNA	Protein	Name
NM_001024.4	NP_001015.1	40S ribosomal protein S21

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10079194	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS21 Protein Structure

Ribosomal_S21e

0
83 a.a.

Protein Preferred Names	Protein Names
40S ribosomal protein S21	8.2 kDa differentiation factor

RPS21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPS21	P63220	RPSA	Homo sapiens	P08865	Anti Tag CoIP	33961781
Intra	RPS21	P63220	RPSA	Homo sapiens	P08865	Y2H Pooling	16169070
Intra	RPS21	P63220	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	RPS21	P63220	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	RPS21	P63220	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	RPS21	P63220	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	RPS21	P63220	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	RPS21	P63220	FHL5	Homo sapiens	Q5TD97	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Tremor, Hereditary Essential, 2	ETM2 Essential Tremor 2 Essential Tremor, Hereditary, 2 Hereditary Essential Tremor 2 Tremor Hereditary Essential, 2
Lactase Deficiency, Congenital	Congenital Lactase Deficiency Disaccharide Intolerance Ii Congenital Alactasia Congenital Alactasia Syndrome Congenital Lactose Intolerance Congenital Lactose Malabsorption Hereditary Alactasia Alactasia, Congenital Cld COLACD Disaccharide Intolerance Type 2 Cld - [Congenital Lactase Deficiency] Disaccharide Intolerance 2 Lactose Intolerance Of Newborn Hereditary Lactase Deficiency
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12233	RPS21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21743	Rps21 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28260	Rps21 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPS21	VGNC	VGNC:34134
Rattus norvegicus	RPS21	RGD	RGD:2323583
Canis familiaris	RPS21	VGNC	VGNC:45735
Mus musculus	RPS21	MGD	MGI:1913731
Macaca mulatta	RPS21	VGNC	VGNC:98438
Others	RPS21	NCBI