CCL18 - C-C motif chemokine ligand 18 Gene

Also Known as CKb7; PARC; AMAC1; DCCK1; MIP-4; AMAC-1; DC-CK1; SCYA18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6362

About CCL18

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,064,272-36,072,032 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 173 orthologues and 25 paralogues. Biased expression in lung (RPKM 88.7), lymph node (RPKM 45.6) and 9 other tissues.

Summary

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

CCL18 Products (1)

mRNA	Protein	Name
NM_002988.4	NP_002979.1	C-C motif chemokine 18 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21481794	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL18 Protein Structure

IL8

0
89 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 18	CC chemokine PARC

CCL18 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCL18	P55774	PITPNM3	Homo sapiens	Q9BZ71	Confocal	21481794
Intra	CCL18	P55774	PITPNM3	Homo sapiens	Q9BZ71	Competition Binding	21481794

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL18 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7265	MIP-4/CCL18 Protein, Human	P55774 (A21-A89)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72759	MIP-4/CCL18 Protein, Human (His)	P55774 (A21-A89)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700545	MIP-4/CCL18 Protein, Human (P. pastoris, His)	P55774 (A21-A89)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Septic Arthritis	Infectious Arthritis Arthritis, Infectious Arthritis Septic Arthritis, Bacterial
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Pulmonary Fibrosis	Fibrosis Of Lung
Niemann-Pick Disease	Sphingomyelin/Cholesterol Lipidosis Niemann-Pick Diseases Lipoid Histiocytosis Sphingomyelin Lipidosis Sphingomyelinase Deficiency Disease Lipid Histiocytosis Neuronal Cholesterol Lipidosis Neuronal Lipidosis Npd Sphingomyelinase Deficiency Niemann-Pick Disease, Type A
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Mansonelliasis	Mansonellosis Mansonella Perstans Infections Mansonella Infestation
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Nonspecific Interstitial Pneumonia	Nsip Non-Specific Interstitial Pneumonia Non-Specific Idiopathic Interstitial Pneumonia Non-Specific Interstitial Pneumonia Nos
Systemic Scleroderma	Scleroderma Progressive Systemic Sclerosis Systemic Sclerosis Scleroderma, Systemic Scleroderma Syndrome Dermatosclerosis Familial Progressive Scleroderma Progressive Scleroderma Scleroderma Disease Scleroderma, Localized Diffuse Scleroderma Scleroderma, Familial Progressive
Idiopathic Interstitial Pneumonia	Hamman-Rich Syndrome Diffuse Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis Ipf Idiopathic Interstitial Pneumonias Idiopathic Interstitial Pneumonia, Not Otherwise Specified Pulmonary Fibrosis
Gaucher Disease, Type I	Glucocerebrosidase Deficiency Acid Beta-Glucosidase Deficiency Gba Deficiency GD1 Gd I Gaucher Disease, Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Type I Gaucher'S Disease Type I Gaucher Disease Gd 1 Non-Cerebral Juvenile Gaucher Disease GD Gaucher Disease 1 Adult Non-Neuronopathic Gaucher Disease Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Gaucher Disease, Type 1
Breast Malignant Phyllodes Tumor	Malignant Cystosarcoma Phyllodes Malignant Phyllodes Tumor Of Breast Malignant Phyllodes Tumour Of Breast Phyllodes Breast Tumor Phyllodes Tumor Of The Breast Breast Malignant Phyllodes Tumour Malignant Mammary Phyllodes Tumor Malignant Mammary Phyllodes Tumour Malignant Phyllodes Neoplasm Malignant Phyllodes Tumor Malignant Phyllodes Tumour Phyllodes Breast Neoplasm Phyllodes Breast Tumour Phyllodes Tumor, Malignant Cystosarcoma Phyllodes Cystosarcoma Phyllodes Of The Breast Phylloides Tumor Malignant Breast Phyllodes Tumor Breast Phyllodes Tumor Phyllodes Tumor Malignant Phyllodes Cystosarcoma Of Unspecified Site
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Gaucher Disease, Type Iii	Gaucher Disease, Subacute Neuronopathic Type Gd Iii Gaucher Disease, Chronic Neuronopathic Type Gaucher Disease, Juvenile And Adult, Cerebral Gaucher Disease Type 3 GD3 Gaucher'S Disease Type Iii Gaucher Disease Type Iii Gd 3 Cerebral Juvenile And Adult Form Of Gaucher Disease Chronic Neuronopathic Gaucher Disease Gaucher Disease 3 Cerebral, Juvenile And Adult, Gaucher Disease Gaucher Disease Chronic Neuronopathic Type Gaucher Disease Type Ii Subacute Neuronopathic Gaucher Disease Type 3 Gaucher Disease Gaucher Disease, Type 3 Gaucher Disease, Type 2
Sphingolipidosis	Sphingolipidoses
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02087	CCL18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174765	Human CCL18 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CCL18	VGNC	VGNC:99132
Mus musculus	CCL18	MGD	MGI:98260
Others	CCL18	NCBI