TNMD - tenomodulin Gene

Homo sapiens

Also known as TEM; CHM1L; BRICD4

Gene ID: 64102 | Gene type: protein coding

About TNMD

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,584,936-100,599,885 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 1 paralogue. Biased expression in fat (RPKM 8.0), placenta (RPKM 1.2) and 2 other tissues.

Summary

This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]

TNMD Products(1)

mRNA	Protein	Name
NM_022144.3	NP_071427.2	tenomodulin

TNMD Protein Structure

BRICHOS

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

tenomodulin

BRICHOS domain containing 4

Related Diseases

Diseases

Alias

Epicondylitis

Tennis Elbow	Lateral Epicondylitis
Golfer'S Elbow	Medial Epicondylitis
Andrel Epicondylitis	Archer'S Elbow
Hockey Elbow	Shooter'S Elbow

Tendinitis

Tendinopathy

Trichothiodystrophy 6, Nonphotosensitive

TTD6	Nonphotosensitive Trichothiodystrophy 6
Trichothiodystrophy 6, Non-Photosensitive

Nonphotosensitive Trichothiodystrophy

Trichothiodystrophy Nonphotosensitive

Amish Brittle Hair Brain Syndrome

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Developmental And Epileptic Encephalopathy 9

Efmr	Epileptic Encephalopathy, Early Infantile, 9
Eiee9	DEE9
Juberg-Hellman Syndrome	Epilepsy, Female-Restricted, With Mental Retardation
Developmental And Epileptic Encephalopathy, 9	Early Infantile Epileptic Encephalopathy 9
Early Infantile Female-Limited Epilecptic Encephalopathy	Female Restricted Epilepsy With Mental Retardation
Juberg Hellman Syndrome	Pcdh19-Related Female-Limited Epilepsy
Epilepsy And Intellectual Disability Limited To Females	Epilepsy, Female Restricted, With Intellectual Disability
Familial Epilepsy And Intellectual Disability Limited To Females	Female Restricted Epilepsy With Intellectual Delays
Pcdh19-Related Fle	Pcdh19-Related Infantile Epileptic Encephalopathy
Female Restricted Epilepsy With Intellectual Disability	Encephalopathy, Epileptic, Early Infantile, Type 9

Bursitis

Bursitis, Not Otherwise Specified

Inflammation Of Bursa

De Quervain Disease

Radial Styloid Tenosynovitis	Tenosynovitis, De Quervain'S
De Quervain'S Disease	Tenosynovitis Of Radial Styloid Process
Stenosans Tenosynovitis

Calcific Tendinitis

Calcific Tendinitis Nos

Sclerocornea

Isolated Congenital Sclerocornea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14846	TNMD Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNMD	VGNC	VGNC:36187
Canis familiaris	TNMD	VGNC	VGNC:47684
Macaca mulatta	TNMD	VGNC	VGNC:79087
Mus musculus	TNMD	MGD	MGI:1929885
Rattus norvegicus	TNMD	RGD	RGD:620938