SCG5 - secretogranin V Gene

Also Known as 7B2; SgV; P7B2; SGNE1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6447

About SCG5

Cytogenetic location: 15q13.3 Genomic coordinates (GRCh38): 15:32,641,710-32,697,092 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 201 orthologues. Biased expression in brain (RPKM 106.2), adrenal (RPKM 48.4) and 4 other tissues.

Summary

This gene encodes a secreted chaperone protein that prevents the aggregation of Other secreted proteins, including proteins that are associated with neurodegenerative and Metabolic Disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

SCG5 Products (4)

mRNA Protein Name
NM_001144757.3 NP_001138229.1 neuroendocrine protein 7B2 isoform 1 precursor
NM_001394278.1 NP_001381207.1 neuroendocrine protein 7B2 isoform 3 precursor
NM_001394279.1 NP_001381208.1 neuroendocrine protein 7B2 isoform 4 precursor
NM_003020.5 NP_003011.1 neuroendocrine protein 7B2 isoform 2 precursor

SCG5 Protein Structure

Secretogranin_V

Secretogranin_V: Neuroendocrine protein 7B2 precursor (Secretogranin V) (13 - 204)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

neuroendocrine protein 7B2

  • pituitary polypeptide

SCG5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCG5 P05408 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
SCG5 P05408 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
SCG5 P05408 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
SCG5 P05408 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
SCG5 P05408 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
SCG5 P05408 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
SCG5 P05408 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
SCG5 P05408 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Serous Labyrinthitis

  • Acute Serous Labyrinthitis
Hereditary Mixed Polyposis Syndrome

  • Hmps
Wolfram Syndrome

  • Didmoad Syndrome

  • Didmoad

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

  • Wfs

  • Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

  • Didmoadud

  • Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

  • Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Lipoma Of Colon

  • Colonic Lipoma

  • Colon Lipoma
Large Intestine Lipoma

  • Lipoma Of Large Intestine

  • Colorectal Lipoma
Narcolepsy 1

  • NRCLP1

  • Narcoleptic Syndrome 1

  • Gelineau Disease

  • Narcolepsy-Cataplexy

  • Narcolepsy-Cataplexy Syndrome

  • Narcolepsy, Type 1

  • Narcolepsy Type 1

  • Cataplexy

  • Gélineau'S Syndrome

  • Narcolepsy With Cataplexy And/Or Hypocretin Deficiency
Ehlers-Danlos Syndrome

  • Eds

  • Cutis Hyperelastica

  • Elastic Skin

  • Ehlers-Danlos Syndromes

  • Ed Syndrome

  • Ehlers Danlos Syndrome

  • Ehlers Danlos Disease

  • Eds - [Ehlers-Danlos Syndrome]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12503 SCG5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22319 Scg5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28841 Scg5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99899 Samrotamab 98.26% Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SCG5 VGNC VGNC:34334
Rattus norvegicus SCG5 RGD RGD:3669
Felis catus SCG5 VGNC VGNC:64910
Canis familiaris SCG5 VGNC VGNC:45907
Mus musculus SCG5 MGD MGI:98289
Others SCG5 NCBI