SCG5 - secretogranin V Gene

Homo sapiens

Also known as 7B2; SgV; P7B2; SGNE1

Gene ID: 6447 | Gene type: protein coding

About SCG5

Cytogenetic location: 15q13.3 Genomic coordinates (GRCh38): 15:32,641,710-32,697,092 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 201 orthologues. Biased expression in brain (RPKM 106.2), adrenal (RPKM 48.4) and 4 other tissues.

Summary

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and Metabolic Disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

SCG5 Products(4)

mRNA	Protein	Name
NM_001144757.3	NP_001138229.1	neuroendocrine protein 7B2 isoform 1 precursor
NM_001394278.1	NP_001381207.1	neuroendocrine protein 7B2 isoform 3 precursor
NM_001394279.1	NP_001381208.1	neuroendocrine protein 7B2 isoform 4 precursor
NM_003020.5	NP_003011.1	neuroendocrine protein 7B2 isoform 2 precursor

SCG5 Protein Structure

Secretogranin_V

0
100
200
212 a.a.

Protein Preferred Names

Protein Names

neuroendocrine protein 7B2

pituitary polypeptide

Related Diseases

Diseases

Alias

Serous Labyrinthitis

Acute Serous Labyrinthitis

Hereditary Mixed Polyposis Syndrome

Hmps

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Lipoma Of Colon

Colonic Lipoma

Colon Lipoma

Large Intestine Lipoma

Lipoma Of Large Intestine

Colorectal Lipoma

Narcolepsy 1

NRCLP1	Narcoleptic Syndrome 1
Gelineau Disease	Narcolepsy-Cataplexy
Narcolepsy-Cataplexy Syndrome	Narcolepsy, Type 1
Narcolepsy Type 1	Cataplexy
Gélineau'S Syndrome	Narcolepsy With Cataplexy And/Or Hypocretin Deficiency

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12503	SCG5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCG5	VGNC	VGNC:34334
Rattus norvegicus	SCG5	RGD	RGD:3669
Felis catus	SCG5	VGNC	VGNC:64910
Canis familiaris	SCG5	VGNC	VGNC:45907
Mus musculus	SCG5	MGD	MGI:98289