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DCLRE1B - DNA cross-link repair 1B Gene

Also Known as DKCB8; SNM1B; SNMIB; APOLLO

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64858

About DCLRE1B

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:113,904,619-113,914,086 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 3.3), appendix (RPKM 3.2) and 25 other tissues.

Summary

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008]

DCLRE1B Products (5)

mRNA	Protein	Name
NM_001319946.2	NP_001306875.1	5' exonuclease Apollo isoform b
NM_001319947.2	NP_001306876.1	5' exonuclease Apollo isoform b
NM_001363690.2	NP_001350619.1	5' exonuclease Apollo isoform c
NM_001363691.2	NP_001350620.1	5' exonuclease Apollo isoform d
NM_022836.4	NP_073747.1	5' exonuclease Apollo isoform a

DCLRE1B Protein Structure

Lactamase_B_2

DRMBL

0
100
200
300
400
500
532 a.a.

Protein Preferred Names	Protein Names
5' exonuclease Apollo	DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)

DCLRE1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCLRE1B	Q9H816	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	DCLRE1B	Q9H816	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	DCLRE1B	Q9H816	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	DCLRE1B	Q9H816	APOE	Homo sapiens	P02649	Y2H Array	32814053
Intra	DCLRE1B	Q9H816	APOE	Homo sapiens	P02649	Y2H Pooling	32814053
Intra	DCLRE1B	Q9H816	APOE	Homo sapiens	P02649	Validated Y2H	32814053
Intra	DCLRE1B	Q9H816	TDP1	Homo sapiens	Q9NUW8	Y2H Array	32814053
Intra	DCLRE1B	Q9H816	TDP1	Homo sapiens	Q9NUW8	Validated Y2H	32814053
Intra	DCLRE1B	Q9H816	TDP1	Homo sapiens	Q9NUW8	Y2H Pooling	32814053
Intra	DCLRE1B	Q9H816	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	DCLRE1B	Q9H816	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	DCLRE1B	Q9H816	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	DCLRE1B	Q9H816	TERF2	Homo sapiens	Q15554	IF	16730175
Intra	DCLRE1B	Q9H816	TERF2	Homo sapiens	Q15554	Pull Down	16730175
Intra	DCLRE1B	Q9H816	TERF2	Homo sapiens	Q15554	Anti Tag CoIP	33961781
Intra	DCLRE1B	Q9H816	TERF2	Homo sapiens	Q15554	Anti Tag CoIP	20479256
Intra	DCLRE1B	Q9H816	TERF2	Homo sapiens	Q15554	TAP	24981860
Intra	DCLRE1B	Q9H816	TERF2	Homo sapiens	Q15554	Anti Tag CoIP	26496610
Intra	DCLRE1B	Q9H816	NDRG1	Homo sapiens	Q92597	Validated Y2H	32814053
Intra	DCLRE1B	Q9H816	NDRG1	Homo sapiens	Q92597	Y2H Array	32814053
Intra	DCLRE1B	Q9H816	NDRG1	Homo sapiens	Q92597	Y2H Pooling	32814053
Intra	DCLRE1B	Q9H816	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	DCLRE1B	Q9H816	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	DCLRE1B	Q9H816	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hoyeraal Hreidarsson Syndrome	Hoyeraal-Hreidarsson Syndrome Progressive Pancytopenia-Immunodeficiency-Cerebellar Hypoplasia Syndrome Cerebellar Hypoplasia With Pancytopenia Growth Retardation Prenatal With Progressive Pancytopenia And Cerebellar Hypoplasia
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Cerebellar Hypoplasia
Interstitial Nephritis, Karyomegalic	Karyomegalic Interstitial Nephritis KMIN Kin Systemic Karyomegaly Karyomegalic Tubulointerstitial Nephritis Ktn
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Adenosine Deaminase Deficiency	Ada Deficiency Ada-Scid Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency Adenosine Deaminase Deficient Severe Combined Immunodeficiency Scid Due To Ada Deficiency Severe Combined Immunodeficiency Due To Ada Deficiency Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency Ada Scid Due To Adenosine Deaminase Deficiency
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03581	DCLRE1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DCLRE1B	VGNC	VGNC:27917
Canis familiaris	DCLRE1B	VGNC	VGNC:39807
Mus musculus	DCLRE1B	MGD	MGI:2156057
Rattus norvegicus	DCLRE1B	RGD	RGD:1310343
Macaca mulatta	DCLRE1B	VGNC	VGNC:71647
Others	DCLRE1B	NCBI