DCLRE1B - DNA cross-link repair 1B Gene

Homo sapiens

Also known as DKCB8; SNM1B; SNMIB; APOLLO

Gene ID: 64858 | Gene type: protein coding

About DCLRE1B

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:113,904,619-113,914,086 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 3.3), appendix (RPKM 3.2) and 25 other tissues.

Summary

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008]

DCLRE1B Products(5)

mRNA	Protein	Name
NM_001319946.2	NP_001306875.1	5' exonuclease Apollo isoform b
NM_001319947.2	NP_001306876.1	5' exonuclease Apollo isoform b
NM_001363690.2	NP_001350619.1	5' exonuclease Apollo isoform c
NM_001363691.2	NP_001350620.1	5' exonuclease Apollo isoform d
NM_022836.4	NP_073747.1	5' exonuclease Apollo isoform a

DCLRE1B Protein Structure

Lactamase_B_2

DRMBL

0
100
200
300
400
500
532 a.a.

Protein Preferred Names

Protein Names

5' exonuclease Apollo

DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)

Related Diseases

Diseases

Alias

Hoyeraal Hreidarsson Syndrome

Hoyeraal-Hreidarsson Syndrome	Progressive Pancytopenia-Immunodeficiency-Cerebellar Hypoplasia Syndrome
Cerebellar Hypoplasia With Pancytopenia	Growth Retardation Prenatal With Progressive Pancytopenia And Cerebellar Hypoplasia

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Cerebellar Hypoplasia

Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis	KMIN
Kin	Systemic Karyomegaly
Karyomegalic Tubulointerstitial Nephritis	Ktn

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Adenosine Deaminase Deficiency

Ada Deficiency	Ada-Scid
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency	Adenosine Deaminase Deficient Severe Combined Immunodeficiency
Scid Due To Ada Deficiency	Severe Combined Immunodeficiency Due To Ada Deficiency
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency	Ada
Scid Due To Adenosine Deaminase Deficiency

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03581	DCLRE1B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DCLRE1B	VGNC	VGNC:27917
Canis familiaris	DCLRE1B	VGNC	VGNC:39807
Mus musculus	DCLRE1B	MGD	MGI:2156057
Rattus norvegicus	DCLRE1B	RGD	RGD:1310343
Macaca mulatta	DCLRE1B	VGNC	VGNC:71647

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