Stx12 - syntaxin 12 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 65033

Summary

Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in synaptic vesicle to endosome fusion. Located in postsynaptic recycling endosome and synaptic vesicle. Is integral component of synaptic vesicle membrane. Orthologous to human STX12 (syntaxin 12). [provided by Alliance of Genome Resources, Apr 2022]

Stx12 Products (1)

mRNA	Protein	Name
NM_022939.2	NP_075228.2	syntaxin-12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12070131	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in endocytic recycling	IDA IDA: Inferred from direct assay	30962439	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	15448273	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	15448273	RGD
involved in synaptic vesicle to endosome fusion	IDA IDA: Inferred from direct assay	17004320	RGD
involved in synaptic vesicle to endosome fusion	IMP IMP: Inferred from mutant phenotype	17004320	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17145503	RGD
is active in postsynaptic recycling endosome membrane	IDA IDA: Inferred from direct assay	17145503	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	30962439	RGD
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	17110340	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	17004320	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
syntaxin-12	Syn13 syntaxin-13

Stx12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Stx12	G3V7P1	Vamp1	Rattus norvegicus	Q63666	Anti Bait CoIP	17717530

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13976	STX12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stx12	NCBI	NCBI:23673