2. Gene
  3. Vamp1 - vesicle-associated membrane protein 1 Gene

Vamp1 - vesicle-associated membrane protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Syb1

Gene ID: 25624 | Gene type: protein coding

About Vamp1

Summary

Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in SNARE complex assembly. Located in terminal bouton. Is active in presynapse. Is integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to human VAMP1 (vesicle associated membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Vamp1 Products(1)

mRNA Protein Name
NM_013090.2 NP_037222.2 vesicle-associated membrane protein 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17717530 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in presynapse EXP
EXP: Inferred from Experiment
24876496 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
24876496 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-associated membrane protein 1

VAMP-1

synaptobrevin-1

Vamp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Vamp1 Q63666 Stx12 Rattus norvegicus G3V7P1
Anti Bait CoIP
17717530
Intra
Vamp1 Q63666 Stx12 Rattus norvegicus G3V7P1
Pull Down
17717530
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10809 VAMP Inhibitor 98.13% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15593 VAMP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vamp1 NCBI NCBI:6843