Ncs1 - neuronal calcium sensor 1 Gene

Rattus norvegicus

Also known as Freq

Gene ID: 65153 | Gene type: protein coding

About Ncs1

Summary

Enables metal ion binding activity; protein kinase binding activity; and voltage-gated Calcium Channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in phosphatidylinositol-mediated signaling; regulation of exocytosis; and regulation of neuron projection development. Located in cytoplasmic vesicle; cytosol; and plasma membrane. Is active in several cellular components, including calyx of Held; postsynaptic cytosol; and presynaptic cytosol. Colocalizes with dense core granule. Orthologous to human NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncs1 Products(1)

mRNA	Protein	Name
NM_024366.2	NP_077342.1	neuronal calcium sensor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	18199453	RGD
enables magnesium ion binding	IDA IDA: Inferred from direct assay	18199453	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16470652	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12244129	RGD
enables voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	17502602	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	12034721	RGD
involved in positive regulation of exocytosis	IDA IDA: Inferred from direct assay	9712909	RGD
involved in positive regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	12034721	RGD
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17502602	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	11910115	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	11910115	RGD
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	12947410	RGD
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	12947410	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in calyx of Held	IDA IDA: Inferred from direct assay	11910115	RGD
is active in calyx of Held	IMP IMP: Inferred from mutant phenotype	11910115	RGD
located in dense core granule	IDA IDA: Inferred from direct assay	9712909	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12947410	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	12947410	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	12351722	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	11910115	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	11910115	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuronal calcium sensor 1

NCS-1	frequenin-like protein
frequenin-like ubiquitous protein

Ncs1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ncs1	P62168	ARF1	Bos taurus	P84080	Pull Down	16470652
Cross	Ncs1	P62168	PDE1A	Bos taurus	P14100	Pull Down	16470652

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122579	IGS-1.76	Inhibitor	98.57%	Unkown
HY-N2037C	(S)-Higenamine hydrobromide		97.85%	Unkown
HY-N2037B	(S)-Higenamine		/	Unkown
HY-RS09102	NCS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121503	FD44		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncs1	NCBI	NCBI:23413

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