Ncs1 - neuronal calcium sensor 1 Gene

Also Known as Freq

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65153

Summary

Enables metal ion binding activity; protein kinase binding activity; and voltage-gated Calcium Channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in phosphatidylinositol-mediated signaling; regulation of exocytosis; and regulation of neuron projection development. Located in cytoplasmic vesicle; cytosol; and plasma membrane. Is active in several cellular components, including calyx of Held; postsynaptic cytosol; and presynaptic cytosol. Colocalizes with dense core granule. Orthologous to human NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncs1 Products (1)

mRNA Protein Name
NM_024366.2 NP_077342.1 neuronal calcium sensor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
18199453 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
18199453 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16470652 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12244129 RGD
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
17502602 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
12034721 RGD
involved in positive regulation of exocytosis IDA
IDA: Inferred from direct assay
9712909 RGD
involved in positive regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
12034721 RGD
involved in regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17502602 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
11910115 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
11910115 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
12947410 RGD
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
12947410 RGD
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
11910115 RGD
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
11910115 RGD
located in dense core granule IDA
IDA: Inferred from direct assay
9712909 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12947410 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
12947410 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
12351722 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
11910115 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
11910115 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal calcium sensor 1

  • NCS-1

  • frequenin-like protein

  • frequenin-like ubiquitous protein

Ncs1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Ncs1 P62168 ARF1 Bos taurus P84080
Pull Down
16470652
Cross
Ncs1 P62168 PDE1A Bos taurus P14100
Pull Down
16470652
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2037C (S)-Higenamine hydrobromide 97.85% Unkown
HY-122579 IGS-1.76 Inhibitor 98.57% Unkown
HY-N2037B (S)-Higenamine / Unkown
HY-RS09102 NCS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121503 FD44 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncs1 NCBI NCBI:23413