SLC16A1 - solute carrier family 16 member 1 Gene

Also Known as MCT; HHF7; MCT1; MCT1D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6566

About SLC16A1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,911,847-112,956,196 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 339 orthologues, 13 paralogues and is associated with 6 phenotypes. Broad expression in heart (RPKM 23.3), colon (RPKM 22.1) and 23 other tissues.

Summary

The protein encoded by this gene is a proton-linked Monocarboxylate Transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

SLC16A1 Products (3)

mRNA	Protein	Name
XM_047428789.1	XP_047284745.1	monocarboxylate transporter 1 isoform X1
NM_001166496.2	NP_001159968.1	monocarboxylate transporter 1
NM_003051.4	NP_003042.3	monocarboxylate transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lactate:proton symporter activity	IDA IDA: Inferred from direct assay	12946269	GOA
enables monocarboxylic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	25371203	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10921872	GOA
enables succinate transmembrane transporter activity	IDA IDA: Inferred from direct assay	32946811	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	23816619	GOA
involved in monocarboxylic acid transport	IDA IDA: Inferred from direct assay	25371203	GOA
involved in succinate transmembrane transport	IDA IDA: Inferred from direct assay	32946811	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15901598	GOA
located in basal plasma membrane	IDA IDA: Inferred from direct assay	26854723	GOA
located in centrosome	IDA IDA: Inferred from direct assay	23816619	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	26854723	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15505343	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC16A1 Protein Structure

MFS_1

0
100
200
300
400
500 a.a.

Protein Preferred Names	Protein Names
monocarboxylate transporter 1	MCT 1 solute carrier family 16 (monocarboxylate transporter), member 1 solute carrier family 16 (monocarboxylic acid transporters), member 1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

SLC16A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83499	Monocarboxylic Acid Transporter 1 Antibody (YA3244)	WB	Human
HY-P83499A	Monocarboxylic Acid Transporter 1 Antibody (YA3244)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Hyperinsulinemic Hypoglycemia	Nesidioblastosis Islet Cell Hyperplasia Persistent Hyperinsulinemia Hypoglycemia Of Infancy Hyperinsulinemic Hypoglycaemia
Diversion Colitis
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Hyperinsulinemic Hypoglycemia, Familial, 7	HHF7 Exercise-Induced Hyperinsulinemic Hypoglycemia Exercise-Induced Hyperinsulinism Familial Hyperinsulinemic Hypoglycemia 7 Eihi Hyperinsulinism Due To Monocarboxylate Transporter 1 Deficiency Hyperinsulinism Due To Slc16a1 Deficiency Hyperinsulinemic Hypoglycemia, Exercise-Induced Exercise Induced Hyperinsulinemic Hypoglycemia Hyperinsulinemic Hypoglycemia Exercise-Induced Hyperinsulinemic Hypoglycemia Familial 7
Hyperinsulinism	Hyperinsulinemia
Monocarboxylate Transporter 1 Deficiency	Ketoacidosis Due To Monocarboxylate Transporter-1 Deficiency MCT1D Ketosis
Erythrocyte Lactate Transporter Defect	Metabolic Myopathy Due To Lactate Transporter Defect Lactate Transporter Defect, Myopathy Due To Symptomatic Deficiency In Lactate Transport SDLT
Asphyxia Neonatorum	Birth Asphyxia Postnatal Asphyxia Asphyxia - Birth Asphyxia, In Liveborn Infant Hypoxia Neonatorum Hypoxia, In Liveborn Infant Intrapartum Asphyxia Neonatal Asphyxia Newborn Asphyxia Asphyxia In Liveborn Infant Asphyxia Of Newborn Nos Perinatal Asphyxia Perinatal Hypoxia Newborn Asphyxiation
Biotin Deficiency	Biotin Deficiency Disease B7 Deficiency Biotan Vitamin Deficiency
Hyperinsulinemic Hypoglycemia, Familial, 6	Hyperinsulinism-Hyperammonemia Syndrome HHF6 Familial Hyperinsulinemic Hypoglycemia 6 Hi/Ha Syndrome Ha/Hi Syndrome Hyperinsulinemic Hypoglycemia Familial 6 Hyperinsulinism Hyperammonemia Syndrome Hhs
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13016	SLC16A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-182416	slCeMM1	Inhibitor	/	Unkown
HY-RS13017	Slc16a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13018	Slc16a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC16A1	VGNC	VGNC:46235
Macaca mulatta	SLC16A1	VGNC	VGNC:77395
Rattus norvegicus	SLC16A1	RGD	RGD:3690
Bos taurus	SLC16A1	VGNC	VGNC:34683
Mus musculus	SLC16A1	MGD	MGI:106013
Others	SLC16A1	NCBI