Nudt12 - nudix hydrolase 12 Gene

Also Known as 0610016O18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67993

Summary

Enables RNA NAD-cap (NMN-forming) hydrolase activity; magnesium ion binding activity; and zinc ion binding activity. Involved in NAD-cap decapping; circadian regulation of gene expression; and mRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in peroxisome. Is expressed in eye. Orthologous to human NUDT12 (nudix hydrolase 12). [provided by Alliance of Genome Resources, Apr 2022]

Nudt12 Products (2)

mRNA Protein Name
NM_001368393.1 NP_001355322.1 NAD-capped RNA hydrolase NUDT12 isoform 2
NM_026497.3 NP_080773.1 NAD-capped RNA hydrolase NUDT12 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA NAD-cap (NMN-forming) hydrolase activity IDA
IDA: Inferred from direct assay
31101919 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
31101919 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
31101919 MGI
Biological Process GO Annotation Evidence References Source
involved in NAD-cap decapping IDA
IDA: Inferred from direct assay
31101919 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
31875550 MGI
involved in mRNA catabolic process IDA
IDA: Inferred from direct assay
31101919 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD-capped RNA hydrolase NUDT12

  • NADH pyrophosphatase NUDT12

  • deNADding enzyme NUDT12

  • nucleoside diphosphate-linked moiety X motif 12

  • nudix (nucleoside diphosphate linked moiety X)-type motif 12

  • nudix (nucleoside diphosphnudix (nucleoside diphosphate linked moiety X)-type motif 12ate

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16965 TH287 Inhibitor 98.99% Unkown
HY-RS09662 NUDT12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-16965A TH287 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nudt12 NCBI NCBI:83594