NUDT12 - nudix hydrolase 12 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83594

About NUDT12

Cytogenetic location: 5q21.2 Genomic coordinates (GRCh38): 5:103,548,855-103,562,789 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 12.0), thyroid (RPKM 10.7) and 24 other tissues.

Summary

Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]

NUDT12 Products (2)

mRNA Protein Name
NM_001300741.2 NP_001287670.1 NAD-capped RNA hydrolase NUDT12 isoform 2
NM_031438.4 NP_113626.1 NAD-capped RNA hydrolase NUDT12 isoform 1

NUDT12 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (17 - 101)

NUDIX-like

NUDIX-like: NADH pyrophosphatase-like rudimentary NUDIX domain (148 - 277)

zf-NADH-PPase

zf-NADH-PPase: NADH pyrophosphatase zinc ribbon domain (280 - 307)

NUDIX

NUDIX: NUDIX domain (329 - 440)

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  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

NAD-capped RNA hydrolase NUDT12

  • NADH pyrophosphatase NUDT12

NUDT12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUDT12 Q9BQG2 BLMH Homo sapiens Q13867
Anti Tag CoIP
33961781
Intra
NUDT12 Q9BQG2 BLMH Homo sapiens Q13867
Y2H Array
31515488
Intra
NUDT12 Q9BQG2 BLMH Homo sapiens Q13867
Validated Y2H
25416956
Intra
NUDT12 Q9BQG2 BLMH Homo sapiens Q13867
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16965 TH287 Inhibitor 98.99% Unkown
HY-RS09662 NUDT12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-16965A TH287 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NUDT12 VGNC VGNC:63912
Mus musculus NUDT12 MGD MGI:1915243
Bos taurus NUDT12 VGNC VGNC:32326
Canis familiaris NUDT12 VGNC VGNC:44025
Rattus norvegicus NUDT12 RGD RGD:1310902
Macaca mulatta NUDT12 VGNC VGNC:75434
Others NUDT12 NCBI