TRB - T cell receptor beta locus Gene

Also Known as TCRB; TRB@

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6957

Summary

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables signaling receptor activity	IDA IDA: Inferred from direct assay	31959982	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell mediated cytotoxicity directed against tumor cell target	IDA IDA: Inferred from direct assay	31959982	GOA
involved in detection of tumor cell	IDA IDA: Inferred from direct assay	31959982	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of alpha-beta T cell receptor complex	IDA IDA: Inferred from direct assay	31959982	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

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Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Granulomatous Slack Skin Disease	Granulomatous Slack Skin
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Pleurisy
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Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y1309	1-Naphthol		99.96%	Unkown
HY-120793	CMC2.24		97.11%	Unkown
HY-RS14501	THRB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14997	TRB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-Y1309S	1-Naphthol-d8		/	Unkown
HY-RS20688	Aatf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-Y1309S1	1-Naphthol-d7		99.44%	Unkown