Art. -Nr.: HY-Y1309

1-Naphthol

(Synonyms: Furro ER; NSC 9586; Nako TRB)

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1-naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media.

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Reinheit: 99.90%
CAS. Nr.: 90-15-3
Formel: C₁₀H₈O
Molecular Weight:144.17

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

1-Naphthol Chemical Structure

CAS. Nr.: 90-15-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	ED₅₀	82 μM Compound: 1-Naphthol	Cytotoxicity against human BXPC-3 cells assessed as cell index incubated for 72 hrs by xCELLigence real time cell analyser method Cytotoxicity against human BXPC-3 cells assessed as cell index incubated for 72 hrs by xCELLigence real time cell analyser method	[PMID: 38903945]
HEK293	IC₅₀	240 μM Compound: 1-Naphthol	Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method	[PMID: 21030469]
HEK293	IC₅₀	280 μM Compound: 1-Naphthol	Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method	[PMID: 21030469]
K562	IC₅₀	>100 μM Compound: 1-Naphthol	Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay	[PMID: 30199251]
RBL-1	IC₅₀	3.6 μM Compound: 1	Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line	[PMID: 2104936]

In Vitro

The ESPT kinetics of 1-Naphthol are sensitive to the availability of proton-accepting waters around the probe microenvironment, which is reflected in the fluorescence decay kinetics of the different protonated forms of the probe. The fluorescence lifetimes of excited anionic and neutral forms of 1-Naphthol allow for direct monitoring of the hydration level in the microenvironment^[1].
1-Naphthol is distributed in all domains of the system: bulk aqueous phase, interfaces, and hydrophobic dry core, and the probe can fully sense all domains. In addition to the usual fluorescence intensity and spectral shifts, the lifetime parameter set of the two protonated forms also plays an important role^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 90-15-3
Appearance Solid
Molecular Weight 144.17
Formel C₁₀H₈O
Color White to off-white
SMILES

OC1=C2C=CC=CC2=CC=C1
Synonyms

Furro ER; NSC 9586; Nako TRB
Structure Classification
- Phenols
- Monophenols
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : 100 mg/mL (693.63 mM; Need ultrasonic)

H₂O : 1 mg/mL (6.94 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.9363 mL

34.6813 mL

69.3626 mL

5 mM

1.3873 mL

6.9363 mL

13.8725 mL

10 mM

0.6936 mL

3.4681 mL

6.9363 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (952 KB)
- English - EN (952 KB)
- Français - FR (952 KB)
- Deutsch - DE (952 KB)
- Norwegian - NO (952 KB)
- Español - ES (952 KB)
- Swedish - SV (952 KB)
- Italian - IT (952 KB)
- Korean - KR (952 KB)
- Portuguese - PT (952 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Swain J, et al. 1-Naphthol as an ESPT fluorescent molecular probe for sensing thermotropic microenvironmental changes of pluronic F127 in aqueous media. Phys Chem Chem Phys. 2015 Jul 14;17(26):16752-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / Ethanol	1 mM	6.9363 mL	34.6813 mL	69.3626 mL	173.4064 mL
H₂O / Ethanol	5 mM	1.3873 mL	6.9363 mL	13.8725 mL	34.6813 mL
Ethanol	10 mM	0.6936 mL	3.4681 mL	6.9363 mL	17.3406 mL
	15 mM	0.4624 mL	2.3121 mL	4.6242 mL	11.5604 mL
	20 mM	0.3468 mL	1.7341 mL	3.4681 mL	8.6703 mL
	25 mM	0.2775 mL	1.3873 mL	2.7745 mL	6.9363 mL
	30 mM	0.2312 mL	1.1560 mL	2.3121 mL	5.7802 mL
	40 mM	0.1734 mL	0.8670 mL	1.7341 mL	4.3352 mL
	50 mM	0.1387 mL	0.6936 mL	1.3873 mL	3.4681 mL
	60 mM	0.1156 mL	0.5780 mL	1.1560 mL	2.8901 mL
	80 mM	0.0867 mL	0.4335 mL	0.8670 mL	2.1676 mL
	100 mM	0.0694 mL	0.3468 mL	0.6936 mL	1.7341 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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1-Naphthol

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Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

1-Naphthol

Metabolism/Protease Compound Library

Natural Product Library

Medicine Food Homology Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Food-Sourced Compound Library

Human Metabolite Library

Mitochondrial Toxicity Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Cosmetic Ingredient Compound Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Environmental Pollutant Compound Library

Mass Spectrometry Natural Product Library

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

1-Naphthol Related Classifications

HY-Y1309 Related Classifications