VDAC3 - voltage dependent anion channel 3 Gene

Also Known as VDAC-3; HD-VDAC3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7419

About VDAC3

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,391,761-42,405,937 (from NCBI)

This gene has 12 transcripts (splice variants), 304 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 97.4), testis (RPKM 53.6) and 25 other tissues.

Summary

This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and Other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

VDAC3 Products (12)

mRNA Protein Name
NM_001135694.3 NP_001129166.1 voltage-dependent anion-selective channel protein 3 isoform 2
NM_001413552.1 NP_001400481.1 voltage-dependent anion-selective channel protein 3 isoform 1
NM_001413553.1 NP_001400482.1 voltage-dependent anion-selective channel protein 3 isoform 3
NM_001413554.1 NP_001400483.1 voltage-dependent anion-selective channel protein 3 isoform 4
NM_001413555.1 NP_001400484.1 voltage-dependent anion-selective channel protein 3 isoform 5
NM_001413556.1 NP_001400485.1 voltage-dependent anion-selective channel protein 3 isoform 6
NM_001413557.1 NP_001400486.1 voltage-dependent anion-selective channel protein 3 isoform 7
NM_001413558.1 NP_001400487.1 voltage-dependent anion-selective channel protein 3 isoform 1
NM_001413559.1 NP_001400488.1 voltage-dependent anion-selective channel protein 3 isoform 8
NM_001413560.1 NP_001400489.1 voltage-dependent anion-selective channel protein 3 isoform 9
NM_001413561.1 NP_001400490.1 voltage-dependent anion-selective channel protein 3 isoform 10
NM_005662.7 NP_005653.3 voltage-dependent anion-selective channel protein 3 isoform 1
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29128334 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
27641616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VDAC3 Protein Structure

Porin_3

Porin_3: Eukaryotic porin (3 - 276)

  • 0
  • 100
  • 200
  • 283 a.a.
Protein Preferred Names Protein Names

voltage-dependent anion-selective channel protein 3

  • outer mitochondrial membrane protein porin 3

VDAC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VDAC3 Q9Y277 VDAC2 Homo sapiens P45880 35271311
Intra
VDAC3 Q9Y277 VDAC1 Homo sapiens P21796 35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
3-Methylglutaconic Aciduria, Type Iii
  • Optic Atrophy

  • 3-Methylglutaconic Aciduria Type 3

  • Costeff Syndrome

  • Mga3

  • Costeff Optic Atrophy Syndrome

  • Optic Atrophy Plus Syndrome

  • Infantile Optic Atrophy With Chorea And Spastic Paraplegia

  • 3-Methylglutaconic Aciduria Type Iii

  • Autosomal Recessive Optic Atrophy Plus Syndrome

  • Autosomal Recessive Optic Atrophy Type 3

  • Opa3 Defect

  • MGCA3

  • Mga, Type Iii

  • Iraqi Jewish Optic Atrophy Plus

  • Mga Type Iii

  • Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia

  • Iraqi-Jewish 'Optic Atrophy Plus'

  • Optic Atrophy 3, Autosomal Recessive

  • Opa3, Autosomal Recessive

  • Opa3-Related 3-Methylglutaconic Aciduria

  • Iraqi-Jewish Optic Atrophy Plus

  • Atrophy Of Optic Disc

  • 3-Alpha Methylglutaconic Aciduria Type Iii

  • Optic Atrophy 3

  • Optic Atrophy Infantile With Chorea And Spastic Paraplegia

  • Autosomal Recessive Opa3

  • Autosomal Recessive Optic Atrophy 3

  • 3-Methylglutaconic Aciduria 3

  • 3-Alpha-Methylglutaconic Aciduria Type 3

  • Optic Atrophy 3 Autosomal Recessive

  • Atrophy, Optic

  • Atrophy, Optic, Plus Syndrome

  • Optic Nerve Atrophy

  • Primary Optic Atrophy

  • Oa - [Optic Atrophy]

  • Second Cranial Nerve Atrophy

  • Second Cranium Nerve Atrophy

Parkinson Disease, Late-Onset
  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus VDAC3 VGNC VGNC:82523
Mus musculus VDAC3 MGD MGI:106922
Macaca mulatta VDAC3 VGNC VGNC:84135
Rattus norvegicus VDAC3 RGD RGD:621577
Canis familiaris VDAC3 VGNC VGNC:48248
Others VDAC3 NCBI