FBXL15 - F-box and leucine rich repeat protein 15 Gene

Also Known as JET; Fbl15; FBXO37

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79176

Summary

Involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of BMP signaling pathway. Located in cytoplasm. Part of SCF ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in kidney (RPKM 4.8), colon (RPKM 3.6) and 24 other tissues.

FBXL15 Products (2)

mRNA Protein Name
NM_001387294.1 NP_001374223.1 F-box/LRR-repeat protein 15
NM_024326.4 NP_077302.3 F-box/LRR-repeat protein 15

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21572392 GOA
Biological Process GO Annotation Evidence References Source
involved in G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21572392 GOA
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
21572392 GOA
involved in positive regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
21572392 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
21572392 GOA
Cellular Component GO Annotation Evidence References Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
21572392 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21572392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXL15 Q9H469 SMURF2 Homo sapiens Q9HAU4
Anti Bait CoIP
21572392
Intra
FBXL15 Q9H469 SMURF2 Homo sapiens Q9HAU4
Anti Tag CoIP
21572392
Intra
FBXL15 Q9H469 SMURF1 Homo sapiens Q9HCE7
Pull Down
21572392
Intra
FBXL15 Q9H469 SMURF1 Homo sapiens Q9HCE7
Anti Tag CoIP
21572392
Intra
FBXL15 Q9H469 SMURF1 Homo sapiens Q9HCE7
Confocal
21572392
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04784 FBXL14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04783 FBXL12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04785 FBXL16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04786 FBXL17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04787 FBXL18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04788 FBXL19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04793 FBXL5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04796 FBXO15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20017 Fbxl5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26520 Fbxl5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown