CALCB - calcitonin related polypeptide beta Gene

Also Known as CALC2; CGRP2; CGRP-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 797

About CALCB

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:15,073,593-15,078,637 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues and 2 paralogues. Restricted expression toward thyroid (RPKM 12.3).

Summary

Predicted to enable Calcitonin receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

CALCB Products (1)

mRNA Protein Name
NM_000728.4 NP_000719.1 calcitonin gene-related peptide 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALCB Protein Structure

Calc_CGRP_IAPP

Calc_CGRP_IAPP: Calcitonin / CGRP / IAPP family (1 - 125)

  • 0
  • 100
  • 127 a.a.
Protein Preferred Names Protein Names

calcitonin gene-related peptide 2

  • beta-CGRP

CALCB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CALCB P10092 CIB1 Homo sapiens Q99828
Y2H Prey Pooling
32296183
Intra
CALCB P10092 CIB1 Homo sapiens Q99828
Validated Y2H
32296183
Intra
CALCB P10092 CIB1 Homo sapiens Q99828
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CALCB Proteins

Cat. No. Product Name Accession Purity
HY-P7706 CALCB Protein, Human (HEK293, hFc) P10092 (A26-F118) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75600 CALCB Protein, Human (HEK293, mFc) P10092 (A26-F118) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Immunodeficiency 17

  • IMD17

  • Cd3-Gamma Deficiency

  • Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive

  • Combined Immunodeficiency Due To Cd3gamma Deficiency

  • Immunodeficiency 17, Cd3 Gamma Deficient

  • Cd3gamma Deficiency

  • Immunodeficiency, Type 17
Thyroid Carcinoma, Familial Medullary

  • Medullary Thyroid Carcinoma

  • Familial Medullary Thyroid Carcinoma

  • MTC

  • Medullary Thyroid Cancer

  • Fmtc

  • Mtc1

  • Thyroid Cancer, Medullary

  • Thyroid Carcinoma, Medullary

  • Familial Mtc

  • Thyroid Carcinoma Medullary

  • Carcinoma, Thyroid, Medullary, Familial

  • Medullary Carcinoma Of Thyroid

  • Medullary Carcinoma With Amyloid Stroma, Unspecified Site

  • Medullary Carcinoma With Amyloid Stroma Of Thyroid
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01829 CALCB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21502 Calcb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28020 Calcb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CALCB RGD RGD:620997
Macaca mulatta CALCB VGNC VGNC:70515
Mus musculus CALCB MGD MGI:2151254
Others CALCB NCBI