PRRT1 - proline rich transmembrane protein 1 Gene

Also Known as NG5; DSPD1; C6orf31; IFITMD7; SynDIG4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80863

About PRRT1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,148,363-32,153,083 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 130 orthologues and 4 paralogues. Biased expression in brain (RPKM 24.0), ovary (RPKM 12.1) and 6 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in several processes, including long-term synaptic depression; protein localization to cell surface; and regulation of AMPA Receptor activity. Predicted to act upstream of or within several processes, including learning or memory; long-term synaptic potentiation; and synapse organization. Predicted to be located in postsynaptic density membrane and synaptic vesicle membrane. Predicted to be active in glutamatergic synapse and membrane. Predicted to be integral component of postsynaptic membrane. [provided by Alliance of Genome Resources, Apr 2022]

PRRT1 Products (2)

mRNA	Protein	Name
NM_001363780.2	NP_001350709.1	proline-rich transmembrane protein 1 isoform 2
NM_030651.4	NP_085154.3	proline-rich transmembrane protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRRT1 Protein Structure

CD225

0
100
200
306 a.a.

Protein Preferred Names	Protein Names
proline-rich transmembrane protein 1	dispanin subfamily D member 1

Related Diseases

Diseases	Alias
Alzheimer Disease 8	Ad8 Alzheimer'S Disease 8 Alzheimer Disease, Familial, 8 Alzheimer Disease, Familial 8 Alzheimer'S Disease 8, Late Onset
Osteogenesis Imperfecta, Type V	Osteogenesis Imperfecta Type 5 OI5 Osteogenesis Imperfecta Type V Oi Type 5 Oi Type V Oi, Type V Oi With Calcification In Interosseous Membranes Type V Oi Osteogenesis Imperfecta 5 Oi-V
Delayed Sleep Phase Disorder	Delayed Sleep Phase Syndrome Delayed Sleep Phase Syndrome, Susceptibility To DSPD Delayed Sleep Phase Disorder, Susceptibility To DSPS Sleep Phase, Delayed, Disorder Sleep Phase Syndrome, Delayed, Susceptibility To
Episodic Kinesigenic Dyskinesia 1	Paroxysmal Kinesigenic Choreoathetosis Paroxysmal Kinesigenic Dyskinesia Dystonia 10 Familial Paroxysmal Kinesigenic Dyskinesia Episodic Kinesigenic Dyskinesia EKD1 Pkc Pkd Dyt10 Familial Pkd Paroxysmal Kinesigenic Choreathetosis Familial Paroxysmal Dystonia Dystonia, Familial Paroxysmal Dyt-Prrt2 Dystonia, Type 10

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106244	DOTATATE		99.94%	Yes
HY-106244A	DOTATATE acetate		99.95%	Unkown
HY-RS11241	PRRT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRRT1	VGNC	VGNC:83449
Canis familiaris	PRRT1	VGNC	VGNC:49684
Felis catus	PRRT1	VGNC	VGNC:102497
Bos taurus	PRRT1	VGNC	VGNC:50003
Mus musculus	PRRT1	MGD	MGI:1932118
Rattus norvegicus	PRRT1	RGD	RGD:1359348
Others	PRRT1	NCBI