Stx4 - syntaxin 4 Gene

Also Known as Stx4a

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81803

Summary

Enables several functions, including SNAP receptor activity; small GTPase binding activity; and spectrin binding activity. Involved in several processes, including exocytosis; membrane fusion; and protein localization to cell surface. Located in several cellular components, including basolateral plasma membrane; neuron projection membrane; and sarcolemma. Part of SNARE complex. Is active in glutamatergic synapse. Orthologous to human STX4 (syntaxin 4). [provided by Alliance of Genome Resources, Apr 2022]

Stx4 Products (1)

mRNA	Protein	Name
NM_031125.2	NP_112387.2	syntaxin-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNAP receptor activity	IDA IDA: Inferred from direct assay	19109692	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	10051443	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10397765	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	11063739	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IDA IDA: Inferred from direct assay	20434989	RGD
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	20434989	RGD
involved in membrane fusion	IDA IDA: Inferred from direct assay	19109692	RGD
involved in protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	32963038	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	10051443	RGD
involved in synaptic vesicle docking	IDA IDA: Inferred from direct assay	7690687	RGD
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	20434989	RGD
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	20434989	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	10051443	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	20434989	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	20434989	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14759605	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	14759605	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20434989	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20434989	RGD
located in neuron projection membrane	IDA IDA: Inferred from direct assay	32963038	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	20434989	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	12388133	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
syntaxin-4	syntaxin 4A (placental)

Stx4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Stx4	Q08850	Snap23	Mus musculus	O09044	Pull Down	24469400
Intra	Stx4	Q08850	Vamp2	Rattus norvegicus	P63045	Anti Bait CoIP	23380067
Intra	Stx4	Q08850	Vamp2	Rattus norvegicus	P63045	Filter Binding	24469400
Intra	Stx4	Q08850	Vamp2	Rattus norvegicus	P63045	Pull Down	24469400
Cross	Stx4	Q08850	Stxbp3	Mus musculus	Q60770	Pull Down	24469400

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13984	STX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stx4	NCBI	NCBI:6810