Stxbp3 - syntaxin binding protein 3 Gene

Also Known as Sxtbp3; Stxbp3a; Unc18-3; Munc-18c

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20912

Summary

Enables syntaxin binding activity. Acts upstream of or within several processes, including cellular response to interferon-gamma; negative regulation of glucose import; and secretion by cell. Located in apical plasma membrane; cytosol; and phagocytic vesicle. Is expressed in embryo. Orthologous to human STXBP3 (syntaxin binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Stxbp3 Products (1)

mRNA	Protein	Name
NM_011504.1	NP_035634.1	syntaxin-binding protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12297296	MGI
enables syntaxin binding	IDA IDA: Inferred from direct assay	12297296	MGI
enables syntaxin binding	IPI IPI: Inferred from physical interaction	15690082	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	15690082	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	19144319	MGI
acts upstream of or within exocytosis	IMP IMP: Inferred from mutant phenotype	19188424	MGI
acts upstream of or within insulin secretion	IMP IMP: Inferred from mutant phenotype	19188424	MGI
acts upstream of or within intracellular glucose homeostasis	IDA IDA: Inferred from direct assay	12297296	MGI
acts upstream of or within intracellular glucose homeostasis	IMP IMP: Inferred from mutant phenotype	12297296	MGI
acts upstream of or within negative regulation of D-glucose import	IDA IDA: Inferred from direct assay	12297296	MGI
acts upstream of or within negative regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	12297296	MGI
acts upstream of or within protein to membrane docking	IMP IMP: Inferred from mutant phenotype	19188424	MGI
acts upstream of or within response to insulin	IDA IDA: Inferred from direct assay	12297296	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	12297296	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18505797	MGI
located in cytosol	IDA IDA: Inferred from direct assay	12297296	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	19144319	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12297296	MGI
is active in plasma membrane	IPI IPI: Inferred from physical interaction	18535671	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
syntaxin-binding protein 3	MUNC-18-3 mammalian homolog of Unc-18c protein unc-18 homolog 3 protein unc-18 homolog C syntaxin binding protein 3A unc-18 homolog 3 unc-18C

Stxbp3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Stxbp3	Q60770	Vamp2	Rattus norvegicus	P63045	Pull Down	19116655
Cross	Stxbp3	Q60770	Stx4	Rattus norvegicus	Q08850	Pull Down	19116655

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13991	STXBP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19270	Stxbp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25759	Stxbp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stxbp3	NCBI	NCBI:6814