STXBP3 - syntaxin binding protein 3 Gene

Also Known as PSP; MUNC18C; UNC-18C; MUNC18-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6814

About STXBP3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:108,746,674-108,809,523 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 25.5), kidney (RPKM 20.8) and 25 other tissues.

Summary

Enables syntaxin binding activity. Involved in negative regulation of calcium ion-dependent exocytosis; neutrophil degranulation; and platelet aggregation. Located in cytosol; plasma membrane; and secretory granule. Is active in presynapse. [provided by Alliance of Genome Resources, Apr 2022]

STXBP3 Products (1)

mRNA Protein Name
NM_007269.4 NP_009200.2 syntaxin-binding protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12773094 GOA
enables syntaxin binding IPI
IPI: Inferred from physical interaction
12773094 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of calcium ion-dependent exocytosis IMP
IMP: Inferred from mutant phenotype
12649283 GOA
involved in neutrophil degranulation IEP
IEP: Inferred from expression pattern
18588921 GOA
involved in platelet aggregation IMP
IMP: Inferred from mutant phenotype
12773094 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
18588921 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18588921 GOA
located in platelet alpha granule IDA
IDA: Inferred from direct assay
12773094 GOA
located in specific granule IDA
IDA: Inferred from direct assay
18588921 GOA
located in tertiary granule IDA
IDA: Inferred from direct assay
18588921 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STXBP3 Protein Structure

Sec1

Sec1: Sec1 family (32 - 576)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
Protein Preferred Names Protein Names

syntaxin-binding protein 3

  • platelet Sec1 protein

Recombinant STXBP3 Proteins

Cat. No. Product Name Accession Purity
HY-P74535 STXBP3 Protein, Human (sf9, His-GST) O00186 (M1-E592) ≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Early Infantile Epileptic Encephalopathy

  • Early Infantile Epileptic Encephalopathy With Burst-Suppression

  • Early Infantile Epileptic Encephalopathy With Suppression Bursts

  • Eiee

  • Early Infantile Epileptic Encephalopathy With Suppression-Bursts

  • Ohtahara Syndrome

  • Encephalopathy, Epileptic, Early Infantile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13991 STXBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19270 Stxbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25759 Stxbp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris STXBP3 VGNC VGNC:46961
Macaca mulatta STXBP3 VGNC VGNC:78051
Felis catus STXBP3 VGNC VGNC:65820
Rattus norvegicus STXBP3 RGD RGD:619968
Mus musculus STXBP3 MGD MGI:107362
Bos taurus STXBP3 VGNC VGNC:35447
Others STXBP3 NCBI