2. Gene
  3. STXBP3 - syntaxin binding protein 3 Gene

STXBP3 - syntaxin binding protein 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PSP; MUNC18C; UNC-18C; MUNC18-3

Gene ID: 6814 | Gene type: protein coding

About STXBP3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:108,746,674-108,809,523 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 25.5), kidney (RPKM 20.8) and 25 other tissues.

Summary

Enables syntaxin binding activity. Involved in negative regulation of calcium ion-dependent exocytosis; neutrophil degranulation; and platelet aggregation. Located in cytosol; plasma membrane; and secretory granule. Is active in presynapse. [provided by Alliance of Genome Resources, Apr 2022]

STXBP3 Products(1)

mRNA Protein Name
NM_007269.4 NP_009200.2 syntaxin-binding protein 3

STXBP3 Protein Structure

Sec1

Sec1: Sec1 family (32 - 576)

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  • 592 a.a.
Protein Preferred Names Protein Names

syntaxin-binding protein 3

platelet Sec1 protein

Recombinant STXBP3 Proteins

Cat. No. Product Name Accession Purity
HY-P74535 STXBP3 Protein, Human (sf9, His-GST) O00186 (M1-E592) ≥95%

Related Diseases

Diseases Alias
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13991 STXBP3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris STXBP3 VGNC VGNC:46961
Macaca mulatta STXBP3 VGNC VGNC:78051
Felis catus STXBP3 VGNC VGNC:65820
Rattus norvegicus STXBP3 RGD RGD:619968
Mus musculus STXBP3 MGD MGI:107362
Bos taurus STXBP3 VGNC VGNC:35447
Others STXBP3 NCBI