STXBP3 Protein, Human (sf9, His-GST)

STXBP3 protein, together with STX4 and VAMP2, may promote insulin-dependent GLUT4 movement and fusion of GLUT4-containing vesicles with the adipocyte cell surface. It interacts directly with DOC2B on the cell membrane (excluding STX4 interaction) and regulates glucose-stimulated insulin secretion. STXBP3 Protein, Human (sf9, His-GST) is the recombinant human-derived STXBP3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

The STXBP3 protein, in conjunction with STX4 and VAMP2, potentially functions in the insulin-dependent movement of GLUT4 and the docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. Additionally, STXBP3 interacts with DOC2B directly at the cell membrane, excluding interaction with STX4, thereby regulating glucose-stimulated insulin secretion. Furthermore, STXBP3 engages in interaction with STX4, indicating its involvement in diverse cellular processes, particularly those related to vesicle trafficking and insulin-responsive glucose transport in adipocytes. These molecular associations underscore the multifaceted role of STXBP3 in cellular dynamics and insulin-regulated pathways.

Human

Sf9 insect cells

N-His;N-GST

O00186 (M1-E592)

6814  [NCBI]

Full Length

MAPPVAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKNGSKLIVFVIGGITYSEVRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSLIKDE

Approximately 96 kDa, based on SDS-PAGE under reducing conditions.

≥ 80%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.